1162675-80-0

Basic information

• Product Name: [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester
• Synonyms: [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester
• CAS NO: 1162675-80-0
• Molecular Weight: 432.898
• Mol File: 1162675-80-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester(1162675-80-0)
• EPA Substance Registry System: [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester(1162675-80-0)

Safety Data

• Hazardous Substances Data: 1162675-80-0(Hazardous Substances Data)

Upstream product

• 1162675-79-7 2-(4-chloro-phenyl)-5,6-difluoro-1H-benzoimidazole 
• 42716-73-4 ethyl 2-bromo-2-cyclohexylacetate 
• 74-11-3 para-chlorobenzoic acid 
• 23860-35-7 cyclohexylacetic acid chloride 
• 76179-40-3 2-amino-4,5-difluoroaniline 
• 90085-61-3 2-bromocyclohexylacetylchloride 

Downstream Products

• 1162675-66-2 [2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-cyclohexyl-acetic acid 
• 1265885-78-6 1-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-1-cyclohexyl-2-methyl-propan-2-ol 
• 1289117-59-4 2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol 

Relevant articles and documents

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Structure-guided lead optimization of recently described benzimidazolyl acetamides addressed the key liabilities of the previous lead compound 1. These efforts culminated in the discovery of 4-{(S)-2-[2-(4-chloro-phenyl)-5,6- difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid 7g, a highly potent and selective FXR agonist with excellent physicochemical and ADME properties and potent lipid lowering activity after oral administration to LDL receptor deficient mice.

CARBOXYL- OR HYDROXYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

This invention relates to novel carboxyl- or hydroxyl-substituted benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.