1162676-07-4

Basic information

• Product Name: [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid
• CAS NO: 1162676-07-4
• Molecular Weight: 368.863
• Mol File: 1162676-07-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid(1162676-07-4)
• EPA Substance Registry System: [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid(1162676-07-4)

Safety Data

• Hazardous Substances Data: 1162676-07-4(Hazardous Substances Data)

Upstream product

• 5292-21-7 Cyclohexylacetic acid 
• 42716-73-4 ethyl 2-bromo-2-cyclohexylacetate 
• 90085-61-3 2-bromocyclohexylacetylchloride 
• 23860-35-7 cyclohexylacetic acid chloride 
• 1162676-06-3 [2-(4-chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester 

Relevant articles and documents

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Structure-guided lead optimization of recently described benzimidazolyl acetamides addressed the key liabilities of the previous lead compound 1. These efforts culminated in the discovery of 4-{(S)-2-[2-(4-chloro-phenyl)-5,6- difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid 7g, a highly potent and selective FXR agonist with excellent physicochemical and ADME properties and potent lipid lowering activity after oral administration to LDL receptor deficient mice.