116380-66-6 Usage
Description
CHOLIC-2,2,4,4-D4 ACID, also known as Cholic Acid-d4, is a labeled analog of Cholic acid (C432600). It is a choleretic agent produced by and isolated from liver cells. Cholic acid is a primary bile acid derived from cholesterol through a multistep process catalyzed by cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. It plays a crucial role in the digestion and absorption of dietary fats and fat-soluble vitamins.
Uses
Used in Pharmaceutical Industry:
CHOLIC-2,2,4,4-D4 ACID is used as an internal standard for the quantification of cholic acid by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). This application is essential for ensuring accurate and reliable measurements of cholic acid levels in various samples, such as biological fluids or pharmaceutical formulations.
Used in Research and Development:
CHOLIC-2,2,4,4-D4 ACID is used as a research tool to study the metabolism and function of cholic acid in the body. It helps researchers understand the role of cholic acid in the synthesis of secondary bile acids, such as deoxycholic acid (DCA), and its impact on cholesterol and phospholipid levels in the body.
Used in Diagnostic Applications:
CHOLIC-2,2,4,4-D4 ACID can be employed in diagnostic assays to detect and monitor cholic acid levels in patients with various liver or gastrointestinal disorders. This information can be valuable for diagnosing and managing conditions related to bile acid metabolism and liver function.
Used in Toxicology Studies:
CHOLIC-2,2,4,4-D4 ACID can be utilized in toxicology studies to investigate the potential toxic effects of cholic acid and its metabolites on different cell types, including intestinal microbiota. This can help researchers understand the mechanisms underlying the observed effects and develop strategies to mitigate any adverse outcomes.
Used in Drug Development:
CHOLIC-2,2,4,4-D4 ACID can be used in the development of new drugs targeting bile acid metabolism or related pathways. By understanding the interactions between cholic acid and its analogs, researchers can design more effective and safer therapeutic agents for the treatment of various diseases, such as cholesterol-related disorders or liver diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 116380-66-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,3,8 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 116380-66:
(8*1)+(7*1)+(6*6)+(5*3)+(4*8)+(3*0)+(2*6)+(1*6)=116
116 % 10 = 6
So 116380-66-6 is a valid CAS Registry Number.