116384-54-4 Usage
Description
Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, monoethyl ester is a complex organic compound with a unique chemical structure. It is characterized by the presence of a phosphonic acid group, an ethoxymethyl moiety, and a monoethyl ester functional group. This molecule is an intermediate in the synthesis of Mono-POM Ethyl Adefovir (M567050), which is an analogue of the antiviral drug Adefovir (A247500) with a mono-POM ester protecting group.
Uses
1. Used in Pharmaceutical Industry:
Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, monoethyl ester is used as an intermediate in the synthesis of antiviral drugs. Its application is primarily for the development of Mono-POM Ethyl Adefovir (M567050), which is an analogue of the antiviral drug Adefovir (A247500). The mono-POM ester protecting group in M567050 enhances the drug's efficacy and safety profile by improving its stability and bioavailability.
2. Used in Antiviral Drug Development:
Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, monoethyl ester plays a crucial role in the development of new antiviral drugs. As an intermediate in the synthesis of Mono-POM Ethyl Adefovir, it contributes to the creation of a more effective and safer antiviral agent. Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, monoethyl
ester helps in the fight against various viral infections by targeting specific viral enzymes and disrupting their replication process.
ester's applications in the pharmaceutical industry are focused on enhancing the efficacy and safety of antiviral drugs, ultimately contributing to the fight against various viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 116384-54-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,3,8 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 116384-54:
(8*1)+(7*1)+(6*6)+(5*3)+(4*8)+(3*4)+(2*5)+(1*4)=124
124 % 10 = 4
So 116384-54-4 is a valid CAS Registry Number.
116384-54-4Relevant articles and documents
Method to improve antiviral activity of nucleotide analogue drugs
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Page/Page column 9; 10; 19, (2017/02/28)
An amino acid conjugate of a cyclic or acyclic nucleoside phosphonate is provided. In some cases, the amino acid conjugate is a tyrosine alkyl amide phosphonate ester conjugate of a cyclic or acyclic nucleoside phosphonate, and is useful as an antiviral c
SYNTHESIS OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS
Holy, Antonin,Rosenberg, Ivan
, p. 2801 - 2809 (2007/10/02)
Diethyl 2-hydroxyethoxymethanephosphonate (VIII) was converted into diethyl 2-halogenoethoxymethanephosphonates IXa and IXb by reaction with triphenylphosphine and tetrachloromethane or tetrabromomethane; analogous reaction of VIII with p-toluenesulfonyl chloride afforded diethyl 2-(p-toluenesulfonyloxy)ethoxymethanephosphonate (IXc).Reaction of sodium salt of adenine with compounds IX led to 9-(2-diethoxyphosphonylmethoxyethyl)adenine (X).Compound X was converted into 9-(2-phosphonylmethoxyethyl)adenine (II) by treatment with bromotrimethylsilane whereas alkaline hydrolysis of X gave ethyl ester Vb.Reaction of 9-(2-hydroxyethyl)adenine (IIIa) or its N6-benzoyl derivative IIIb with dimethyl p-toluenesulfonyloxymethanephosphonate (IV) in the presence of sodium hydride, followed by alkaline hydrolysis yielded methyl ester Va.Morpholide XI reacted with an inorganic phosphate and diphosphate to give 9-(2-phosphorylphosphonylmethoxyethyl)adenine (XII) and 2-(diphosphorylphosphonylmethoxyethyl)adenine (XIII), respectively.