116387-23-6

Basic information

• Product Name: diethyl N-(4-ethynylbenzoyl)-L-glutamate
• Synonyms: diethyl N-(4-ethynylbenzoyl)-L-glutamate
• CAS NO: 116387-23-6
• Molecular Weight: 331.368
• Mol File: 116387-23-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: diethyl N-(4-ethynylbenzoyl)-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl N-(4-ethynylbenzoyl)-L-glutamate(116387-23-6)
• EPA Substance Registry System: diethyl N-(4-ethynylbenzoyl)-L-glutamate(116387-23-6)

Safety Data

• Hazardous Substances Data: 116387-23-6(Hazardous Substances Data)

Upstream product

• 16450-41-2 L-glutamic acid diethyl ester 
• 10602-00-3 4-Ethynyl-benzoic acid 
• 111291-97-5 4-ethynylbenzoic acid tert-butyl ester 
• 51766-21-3 Phenyl N-phenylphosphoramidochloridate 
• 586-75-4 4-chlorobenzoyl chloride 
• 59247-47-1 tert-butyl-4-bromobenzoate 
• 111291-96-4 tert-butyl 4-<(trimethylsilyl)ethynyl>benzoate 
• 1118-89-4 diethyl-L-glutamate hydrochloride 

Downstream Products

• 116387-28-1 diethyl N-<4-<<2-(pivaloylamino)-4-hydroxy-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl>ethyl>benzoyl>-L-glutamate 
• 95693-76-8 (6RS)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid 
• 116387-24-7 diethyl N-<4-<<2-(pivaloylamino)-4-hydroxypyrido<2,3-d>pyrimidin-6-yl>ethynyl>benzoyl>-L-glutamate 
• 149765-28-6 diethyl N-<2-pivaloylamino-4-methoxy<(pyrrolo<2,3-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate 
• 149765-17-3 diethyl N-<2-pivaloylamino-4-chloro<(pyrrolo<2,3-d>pyrimidin-5-yl)ethynyl>benzoyl>-L-glutamate 

Relevant articles and documents

Process for the preparation of fused pyridine compounds

2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl]pyrido[2,3,-d]pyrimidines and 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimidines are prepared through the reaction of a haloaromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineoplastic agents. A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.