116632-39-4

Basic information

• Product Name: 5-BROMO-2-IODOTOLUENE
• Synonyms: 1-Iodo-2-methyl-4-bromobenzene;5-Bromo-2-iodotoluene 98%;2-iodo-5-bromo-toluene;1-BROMO-4-IODO-5-METHYLBENZENE;5-BROMO-2-IODOTOLUENE;Bromoiodotoluene;5-BROMO-2-IODOTOLUENE, 98+%;4-Bromo-1-iodo-2-methylbenzene
• CAS NO: 116632-39-4
• Molecular Formula: C₇H₆BrI
• Molecular Weight: 296.93
• EINECS: -0
• Product Categories: Aromatic Halides (substituted);Halogen toluene;Bromine Compounds;Iodine Compounds;Aryl;C7;Halogenated Hydrocarbons
• Mol File: 116632-39-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 263 °C(lit.)
• Flash Point: >230 °F
• Appearance: clear slightly yellow to light red-pink liquid
• Density: 2.08 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0161mmHg at 25°C
• Refractive Index: n20/D 1.65(lit.)
• Storage Temp.: Room temperature.
• Sensitive: Light Sensitive
• BRN: 2325157
• CAS DataBase Reference: 5-BROMO-2-IODOTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-IODOTOLUENE(116632-39-4)
• EPA Substance Registry System: 5-BROMO-2-IODOTOLUENE(116632-39-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 116632-39-4(Hazardous Substances Data)

Usage

Description

5-Bromo-2-iodotoluene is a halogenated hydrocarbon characterized by its clear slightly yellow to light red-pink liquid appearance. It is known for undergoing chemoselective Suzuki reactions with phenylboronic acid, which results in the formation of the corresponding carboxylic acid.

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-iodotoluene is used as a medical intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical properties allow it to be a valuable building block in the development of new drugs and medications.
Used in Organic Synthesis:
In the field of organic chemistry, 5-Bromo-2-iodotoluene serves as a key intermediate in the synthesis of a wide range of organic compounds. Its reactivity and functional group compatibility make it a versatile starting material for creating complex molecules and structures.

InChI:InChI=1/C7H6BrI/c1-5-4-6(8)2-3-7(5)9/h2-4H,1H3

Upstream product

• 615-37-2 ortho-methylphenyl iodide 
• 583-75-5 4-Bromo-2-methylaniline 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 589-87-7 1,4-bromoiodobenzene 
• 37614-58-7 3-(4-bromophenyl)prop-2-yn-1-ol 

Downstream Products

• 5411-53-0 5-bromo-2,4-dinitro-toluene 
• 5002-26-6 3-methyl-4-phenylbromobenzene 
• 778581-56-9 2-(4-bromo-2-methylphenyl)-thiophene 
• 918150-44-4 2-methyl-4-(4-ethoxyphenylethynyl)bromobenzene 
• 778581-59-2 5-bromo-2-(4-bromo-2-methylphenyl)-thiophene 
• 230962-37-5 (R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-(2-methyl-1,1'-biphenyl-4-yl)-pentanoic acid 
• 230962-34-2 4-(S)-benzyl-3-{5-(3-methyl-4-phenylphenyl)pentanoyl}oxazolidin-2-one 
• 230962-35-3 tert-butyl (3R)-3-[(4-(S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl)carbonyl]-6-(3-methyl-4-phenylphenyl)hexanoate 
• 230961-21-4 UK-370106 
• 230961-86-1 tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate 
• 230961-47-4 (2R)-N₁-[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]-2-{3-(3-methyl-4-phenylphenyl)propyl}-(N₄-3-propenyloxy)butanediamide 
• 866930-35-0 3-(4-bromo-2-methyl-phenyl)-propionaldehyde 
• 866930-24-7 (4-bromo-2-methyl-phenyl)-[2-(4-methyl-piperidin-1-yl)-ethyl]-amine 
• 866930-92-9 (4-bromo-2-methyl-phenyl)-acetic acid tert-butyl ester 

Relevant articles and documents

Discovery of 5-(2-chloro-4′-(1H-imidazol-1-yl)-[1,1′-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD

Endogenous nitrosothiols (SNOs) including S-nitrosoglutathione (GSNO) serve as reservoir for bioavailable nitric oxide (NO) and mediate NO-based signaling, inflammatory status and smooth muscle function in the lung. GSNOR inhibition increases pulmonary GS

ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS

This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.