116632-54-3

Basic information

• Product Name: 2-Chloro-3-aminoquinoline
• Synonyms: 2-Chloro-3-aminoquinoline;2-Chloro-quinolin-3-ylamine;2-Chloro-3-quinolinamine;2-chloroquinolin-3-aMine;3-AMino-2-chloroquinoline
• CAS NO: 116632-54-3
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.62
• Mol File: 116632-54-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 168℃
• Boiling Point: 320℃
• Flash Point: 147℃
• Appearance: /
• Density: 1.363
• PKA: 0.84±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-aminoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-aminoquinoline(116632-54-3)
• EPA Substance Registry System: 2-Chloro-3-aminoquinoline(116632-54-3)

Safety Data

• Hazardous Substances Data: 116632-54-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-aminoquinoline is a chemical compound with the molecular formula C9H7ClN2. It is an aromatic compound that belongs to the quinoline class of chemicals. 2-Chloro-3-aminoquinoline is characterized by the presence of a chlorine atom and an amino group on the quinoline ring. 2-Chloro-3-aminoquinoline has a variety of industrial and laboratory applications, including its use as an intermediate in the synthesis of pharmaceuticals, dyes, and agrochemicals. It also has potential utility as a building block in the development of novel organic compounds for various purposes. Additionally, 2-Chloro-3-aminoquinoline may possess biological activities that warrant further investigation for potential medicinal or biological applications.

Upstream product

• 5873-00-7 3-amino-quinolin-2-ol 
• 742698-74-4 tert-butyl (2-chloroquinolin-3-yl)carbamate 
• 1607439-99-5 3-azido-2-chloroquinoline 
• 128676-84-6 (2-chloroquinolin-3-yl)boronic acid 
• 73776-25-7 2-chloro-3-quinolinecarboxylic acid 

Downstream Products

• 102469-77-2 N²,N³-diphenyl-quinoline-2,3-diyldiamine 
• 116600-20-5 1,3-diphenyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one 
• 102467-26-5 N²,N³-dinitroso-N²,N³-diphenyl-quinoline-2,3-diyldiamine 
• 71316-38-6 3-amino-quinoline-2-thiol 
• 1620098-27-2 1-methyl-3-(3-{[4-(1H-pyrazol-4-yl)pyrimidin-2-yl]oxy}phenyl)-1H-pyrrolo[3,2-b]quinoline 
• 1620098-28-3 3-(3-{[4-(4-fluorophenyl)pyrimidin-2-yl]oxy}phenyl)-1-methyl-1H-pyrrolo[3,2-b]quinoline 
• 1620098-29-4 3-(3-{[4-(4-methoxyphenyl)pyrimidin-2-yl]oxy}phenyl)-1-methyl-1H-pyrrolo[3,2-b]quinoline 
• 1620098-30-7 3-[3-(4,5'-bipyrimidin-2-yloxy)phenyl]-1-methyl-1H-pyrrolo[3,2-b]quinoline 
• 1620098-31-8 1-methyl-3-(3-{[4-(morpholin-4-yl)pyrimidin-2-yl]oxy}phenyl)-1H-pyrrolo[3,2-b]quinoline 
• 1620098-32-9 1-methyl-3-(3-{[3-(pyrimidin-5-yl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrolo[3,2-b]quinoline 
• 1620098-16-9 3-(4-{[3-(4-fluorophenyl)pyrazin-2-yl]oxy}phenyl)-1-methyl-1H-pyrrolo[3,2-b]quinoline 
• 1620098-17-0 3-(4-{[3-(4-methoxyphenyl)pyrazin-2-yl]oxy}phenyl)-1-methyl-1H-pyrrolo[3,2-b]quinoline 
• 1620098-18-1 1-methyl-3-(4-{[3-(pyridin-4-yl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrolo[3,2-b]quinoline 
• 1620098-19-2 1-methyl-3-(4-{[3-(pyrimidin-5-yl)pyrazin-2-yl]oxy}phenyl)-1H-pyrrolo[3,2-b]quinoline 

Relevant articles and documents

Structure-based design of novel human toll-like receptor 8 agonists

Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds might be promising candidate vaccine adjuvants. Recently, a C2-butyl furo[2,3-c]

Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part II

We report the design and synthesis of novel pyrrolo[3,2-b]quinoline containing heteroarene ethers as PDE10A inhibitors with good to excellent potency, selectivity and metabolic stability. Further optimization of this primary series resulted in the identif