116781-15-8

Basic information

• Product Name: (2S,5R)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan
• CAS NO: 116781-15-8
• Molecular Weight: 480.579
• Mol File: 116781-15-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,5R)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan(116781-15-8)
• EPA Substance Registry System: (2S,5R)-2-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan(116781-15-8)

Safety Data

• Hazardous Substances Data: 116781-15-8(Hazardous Substances Data)

Upstream product

• 5438-36-8 5-iodovaniline 
• 113790-67-3 1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 116681-60-8 1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol 
• 133095-89-3 tert-Butyl-[(S)-5-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-tetrahydro-furan-2-yloxy]-dimethyl-silane 
• 133095-93-9 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid tert-butyl ester 
• 133117-06-3 (S)-5-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-dihydro-furan-2-one 
• 133095-97-3 (S)-5-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-tetrahydro-furan-2-ol 
• 133095-92-8 4-(3-Iodo-5-methoxy-4-propoxy-phenyl)-4-oxo-butyric acid tert-butyl ester 
• 133095-96-2 (S)-5-(3-Methoxy-5-methylsulfanyl-4-propoxy-phenyl)-dihydro-furan-2-one 
• 133095-94-0 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid 
• 133095-95-1 4[3-Methoxy-4-n-propyloxy-5-iodophenyl]-4S-butyrolactone 
• 106331-89-9 3-methoxy-4-n-propyloxy-5-iodobenzaldehyde 
• 116681-64-2 (S)-4-Hydroxy-4-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-butan-1-one 

Downstream Products

• 129314-27-8 trans-2-(3-methoxy-5-methylsulfonyl-4-n-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 

Relevant articles and documents

New 2,5-diaryl tetryhydrofurans and analogs thereof as paf antagonists

Compounds of formula: are disclosed wherein R and R1 are (a) hydrogen;(b) haloloweralkyl;(c) halo;(d) CONR2R3 wherein R2 and R3 independently represent hydrogen, C1-8 alkyl, or C3-8 cycloalkyl;(e) loweralkenyl;(f)-COR2;(g)-CH?OR2;(h) loweralkynyl;(i)-CH?NR2R3;(j)-CH?SR2;(k) =O; or(l)-OR2;(m)-R2; Ar and Ar1 are (a) phenyl or substituted phenyl of formula where R?-R? independently represent H; R2; YO-wherein Y is loweralkenyl, loweralkynyl,-CH? ,-CH?C(O) OR2,-CH?OR2,-CH?C3-8cycloalkyl,-CH? Ar2 wherein Ar2 is phenyl or substituted phenyl,-CH?-CH(OH)-CH? OH; R2S-(O)n wherein R2 can only be C3-8 cycloalkyl and n is 0 to 2; CF?SO, CF?SO?;-CONR2R3;-NR2COR3;-OCONH?-CR2R3R? wherein R? is the same as or different from R2;-CH?OR2;-CH?CO?R2;-CH?OCOR3;-CH?O-CO-OR2;-NHCH?COOR2; halo; or N?R2R3R?X? wherein X? is an anion;(b) monoheteroaryl, di-or polyheteroaryl or fused heteroaryl containing 1 to 3 of any one or more of the heteroatoms N, S or O;(c) heteroarylalkyl;(d) heterocycloalkyl; or(e) heterocycloalkenyl. These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities.

ENANTIOSELECTIVE CYCLIZATION OF CHIRAL BUTANE-1,4-DIOLS TO CHIRAL TETRAHYDROFURANS: SYNTHESIS OF CHIRAL TRANS-2-(3-METHOXY-5-METHYLSULFONYL-4-PROPOXYPHENYL-5-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN (L-659,989), A POTENT PAF-RECEPTOR ANTAGONIST

Acid catalyzed cyclization of (1R,4RS)- and(1S,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diols to the corresponding chiral cis- and trans-tetrahydrofurans proceeds with retention of configuration at C-1.Using