116817-77-7 Usage
Description
(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride is a chemical compound with the molecular formula C22H24N2S.HCl. It is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that is used as an antidepressant medication.
Used in Pharmaceutical Industry:
(+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride is used as an antidepressant medication for the treatment of major depressive disorder and other mood disorders. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps to alleviate symptoms of depression and anxiety.
The hydrochloride salt form of this compound improves its solubility and stability, making it suitable for use as a pharmaceutical ingredient. As a medication, it is typically taken orally in the form of capsules or tablets, and it has demonstrated effectiveness in the treatment of major depressive disorder and other mood disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 116817-77-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,8,1 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 116817-77:
(8*1)+(7*1)+(6*6)+(5*8)+(4*1)+(3*7)+(2*7)+(1*7)=137
137 % 10 = 7
So 116817-77-7 is a valid CAS Registry Number.
116817-77-7Relevant articles and documents
AN IMPROVED PROCESS FOR THE PREPARATION OF DULOXETINE HYDROCHLORIDE
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Page/Page column 7, (2011/07/09)
The present disclosure provides solution to the problem associated in the preparation of duloxetine hydrochloride. This disclosure is successful in preventing the racemization and thereby prevents the formation of unwanted isomer of duloxetine hydrochloride. In addition, the disclosure provides a simple technique for removal of unreacted reactant, 1-fluoronapthalene used as a reactant in the process to obtain (S)-(+)-N-methyl-3(1-naphthalenyloxy)-3-(2-thienyl)propanamine hydrochloride, compound of formula (VI).
Process for the Preparation of 1-Naphthol Mixed Ethers and Intermediates of Crystalline Forms of (+) and (-)-Duloxetine
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Page/Page column 3, (2008/12/09)
The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed.
Process for making duloxetine and related compounds
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Page/Page column 7, (2008/12/06)
A compound of formula 10 is useful in making duloxetine.
