116846-77-6 Usage
Type
Synthetic steroid hormone and progestin medication
Medical Uses
Treatment of gynecological disorders such as menstrual disturbances and endometriosis
Hormone replacement therapy
Chemical Structure
Chlorinated steroid backbone
Hydroxyl group at the 17α position
Methyl group at the 16β position
Mechanism of Action
Binds to progesterone receptors in the body
Leads to physiological effects:
Inhibition of ovulation
Regulation of the menstrual cycle
Support of pregnancy
Dosage Forms
Available in various forms including oral tablets
Common Usage
Often used in combination with other hormonal medications for therapeutic effects.
Check Digit Verification of cas no
The CAS Registry Mumber 116846-77-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,8,4 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 116846-77:
(8*1)+(7*1)+(6*6)+(5*8)+(4*4)+(3*6)+(2*7)+(1*7)=146
146 % 10 = 6
So 116846-77-6 is a valid CAS Registry Number.
116846-77-6Relevant articles and documents
Preparation method of clobetasol propionate
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Paragraph 0056-0058, (2018/03/25)
The invention provides a brand new synthesis route for preparation of clobetasol propionate; adopted raw materials are cheaper and are easier to obtain, reactive raw materials are hydroxylated and then chloridized, carbonyl protection groups are removed, five-membered ring double bonds are subjected to selective oxidation and reduction, after esterification, six-membered ring double bonds are subjected to epoxidation, and then fluorination ring opening is performed to obtain the clobetasol propionate product. The reaction process is easy to operate, the yield of each step is relatively high, the purity of the obtained product is higher, the formation of by-products is effectively avoided, the production cost is reduced and industrialized production is facilitated.
