116850-28-3

Basic information

• Product Name: 2-CHLORO-3-FLUOROTOLUENE
• Synonyms: 2-CHLORO-3-FLUOROTOLUENE;2-Chloro-3-fluorotoluene 99%;2-Chloro-1-fluoro-3-methylbenzene;2-Chloro-3-fluorotoluene99%
• CAS NO: 116850-28-3
• Molecular Formula: C7H6ClF
• Molecular Weight: 144.57
• EINECS: 285-407-3
• Product Categories: Fluorin-contained toluene series;Halogen toluene
• Mol File: 116850-28-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 164.4 °C at 760 mmHg
• Flash Point: 53.5 °C
• Appearance: /
• Density: 1.186 g/cm³
• Vapor Pressure: 2.58mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-3-FLUOROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-FLUOROTOLUENE(116850-28-3)
• EPA Substance Registry System: 2-CHLORO-3-FLUOROTOLUENE(116850-28-3)

Safety Data

• Hazardous Substances Data: 116850-28-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-fluorotoluene is an organic compound with the chemical formula C7H6ClF. It is a colorless to pale yellow liquid that is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes. This chemical is a halogenated toluene derivative, with a chloro group and a fluorine group attached to the benzene ring. It is a highly flammable and potentially hazardous substance, as exposure to 2-chloro-3-fluorotoluene can cause irritation to the skin, eyes, and respiratory system. Additionally, prolonged or high-level exposure can be harmful to human health and the environment. Therefore, proper precautions should be taken when handling, storing, or disposing of this chemical.

InChI:InChI=1/C7H6ClF/c1-5-3-2-4-6(9)7(5)8/h2-4H,1H3

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 352-70-5 m-Fluorotoluene 
• 15068-35-6 2-chloro-3-methylbenzoic acid 

Downstream Products

• 1099597-97-3 2-chloro-3-fluorobenzotrifluoride 
• 64248-59-5 1,2-difluoro-3-(trifluoromethyl)benzene 

Relevant articles and documents

Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 °C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Continuous production method for industrially preparing 2,3-difluorobenzotrifluoride and 3,4-difluorobenzonitrile

The invention discloses a continuous production method for industrially preparing 2,3-difluorobenzotrifluoride and 3,4-difluorobenzonitrile. The preparation process of the 2,3-difluorobenzotrifluoride comprises the preparation step of an intermediate raw material for benzene sulfonamide and benzenesulfonylurea herbicides, and the preparation process of the 3,4-difluorobenzonitrile comprises the preparation step of a cthalofop-butyl intermediate raw material. The method is suitable for industrial production; and compared with the prior art, the method has the advantages of low cost, high production method and less pollution.