1169768-30-2

Basic information

• Product Name: Linolenic acid ketone
• Synonyms: (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-one; heptatriaconta-6,9,28,31-tetraen-19-one; dilinoleyl ketone
• CAS NO: 1169768-30-2
• Molecular Formula: C₃₇H₆₆O
• Molecular Weight: 526.91900
• Mol File: 1169768-30-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Linolenic acid ketone(CAS DataBase Reference)
• NIST Chemistry Reference: Linolenic acid ketone(1169768-30-2)
• EPA Substance Registry System: Linolenic acid ketone(1169768-30-2)

Safety Data

• Hazardous Substances Data: 1169768-30-2(Hazardous Substances Data)

Upstream product

• 1169768-28-8 (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-ol 
• 4102-60-7 (Z,Z)-octadeca-9,12-dienyl bromide 
• 51154-39-3 (9Z,12Z)-octadeca-9,12-dienyl methanesulfonate 
• 1169768-27-7 (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl formate 
• 506-43-4 Linoleyl alcohol 
• 60-33-3 linoleic acid 
• 4102-60-7 18-bromo-octadeca-6,9-diene 

Downstream Products

• 1190197-97-7 2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane 

Relevant articles and documents

Synthesis method of DLin-MC3-DMA intermediate

The invention provides a synthesis method of a DLin-MC3-DMA intermediate, the DLin-MC3-DMA intermediate is (6Z, 9Z, 28Z, 31Z)-triheptane-6, 9, 28, 31-tetraen-19-alcohol, and the synthesis method comprises the following steps: S1, carrying out substitution reaction on (6Z, 9Z)-18-bromooctadecane-6, 9-diene and nitromethane to obtain (6Z, 9Z, 28Z, 31Z), step S2, carrying out hydrolysis reaction on (6Z, 9Z, 28Z, 31Z)-19-nitrotriheptane-6, 9, 28, 31-tetraene to obtain (6Z, 9Z, 28Z, 31Z)-triheptane 6, 9, 28, 31-tetraen-19-ketone, and S3, the (6Z, 9Z, 28Z, 31Z)-triheptane-6, 9, 28, 31-tetraen-19-oneand a reducing agent are subjected to a reduction reaction, (6Z, 9Z, 28Z, 31Z)-triheptan-6, 9, 28, 31-tetraen-19-alcohol is obtained, and the reducing agent comprises sodium borohydride, potassium borohydride, lithium aluminum hydride or a mixture of sodium borohydride, potassium borohydride and lithium aluminum hydride. The synthesis method disclosed by the invention has the characteristics of simple process conditions, simplicity and convenience in operation, short route, high repeatability, higher total yield and contribution to industrial production.

IMPROVED COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS

The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Site specific delivery of nucleic acids by combining targeting ligands with endosomolytic components

The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.