1172603-97-2

Basic information

• Product Name: (2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide
• Synonyms: (2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide
• CAS NO: 1172603-97-2
• Molecular Weight: 183.13
• Mol File: 1172603-97-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide(1172603-97-2)
• EPA Substance Registry System: (2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide(1172603-97-2)

Safety Data

• Hazardous Substances Data: 1172603-97-2(Hazardous Substances Data)

Usage

General Description

(2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide is a chemical compound with the molecular formula C6H8F3NO2. It is a fluoroalkene amide that is used in organic synthesis and pharmaceutical research. (2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide is known for its potential as a building block in the development of new drugs and agrochemicals. It has also been studied for its biological activity and potential use as a chemical intermediate in various industries. Additionally, (2E)-4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide is considered to be a valuable tool in the field of medicinal chemistry and drug discovery due to its unique chemical properties and reactivity. Overall, this compound has a wide range of potential applications in the fields of pharmaceuticals, agrochemicals, and organic synthesis.

Upstream product

• 406-94-0 4,4,4-trifluorobut-2-enoic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 124931-12-0 diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 406-94-0 (E)-4,4,4-trifluorobut-2-enoate 

Downstream Products

• 114192-88-0 (E)-4,4,4-trifluoro-1-phenylbut-2-en-1-one 

Relevant articles and documents

An efficient and safe method for the multigram synthesis of trans -2-(trifluoromethyl)cyclopropylamine

trans-2-(Trifluoromethyl)cyclopropylamine was prepared on a multigram scale from readily accessible 4,4,4-trifluorobut-2-enoic acid in five steps. The key step was a high-yielding cyclopropane ring formation from 4,4,4-trifluorobut-2- enoic acid methoxymethyl amide under Corey-Chaykovsky reaction conditions. Georg Thieme Verlag Stuttgart New York.

BICYCLIC JAK INHIBITORS AND USES THEREOF

Provided herein are compounds of Formulas (I), (II), (III), and (IV) and subformulas thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), (II), (III), or (IV) and methods of using the compounds, e.g., in the treatment of immune disorders, inflammatory disorders, and cancer.

PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.