117309-39-4 Usage
Description
[Benzenesulfonyl-(2-chloro-phenyl)-amino]-acetic acid is a sulfonamide compound characterized by a benzenesulfonyl group attached to an aminoacetic acid molecule, featuring a 2-chloro-phenyl substituent. This chemical structure endows it with potential applications in the field of medicinal chemistry, particularly as an enzyme inhibitor, and holds promise for pharmaceutical research and development.
Uses
Used in Pharmaceutical Industry:
[Benzenesulfonyl-(2-chloro-phenyl)-amino]-acetic acid is used as an enzyme inhibitor for the development of drugs targeting various diseases. Its unique chemical structure allows it to interact with specific enzymes, potentially disrupting their function and offering therapeutic benefits.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, [Benzenesulfonyl-(2-chloro-phenyl)-amino]-acetic acid serves as a promising candidate for further research and development. Its properties and interactions with biological targets can be explored to design novel drugs with improved efficacy and selectivity.
Used in Drug Design:
[Benzenesulfonyl-(2-chloro-phenyl)-amino]-acetic acid is utilized in the design of drugs, where its chemical structure can be optimized to enhance its potency, selectivity, and pharmacokinetic properties. This may lead to the development of new therapeutic agents for the treatment of various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 117309-39-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,3,0 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 117309-39:
(8*1)+(7*1)+(6*7)+(5*3)+(4*0)+(3*9)+(2*3)+(1*9)=114
114 % 10 = 4
So 117309-39-4 is a valid CAS Registry Number.
117309-39-4Relevant articles and documents
N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase
DeRuiter, Jack,Borne, Ronald F.,Mayfield, Charles A.
, p. 145 - 151 (2007/10/02)
A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.
