1173241-20-7Relevant articles and documents
Synthesis and biological evaluation of analogs of methyl ursolate 3-o-chacotrioside as H5N1 viral entry inhibitors
Ren, Sumei,Chen, Qing,Ding, Ning,Zhang, Wei,Li, Yingxia,Guo, Ying
, p. 647 - 658 (2013/01/16)
The earliest stage of influenza virus infection is the viral entry to the host cell. In our previous work, we discovered the first three small molecule H5N1 viral entry inhibitors 1-3. Here, based on saponin 3, methyl ursolate 3-O-chacotrioside, several analogs were synthesized and evaluated to understand the structure-activity relationships of this type of compound on the H5N1 viral entry inhibitory activity. The preliminary studies demonstrated that unlike saponins 1 and 2, it is possible to reduce the 3-O-chacotriosyl residue of compound 3 to a disaccharide without affecting the viral entry activities significantly. The results obtained will render new clues to the understanding of the antiviral profile for these types of compounds.