1173492-73-3

Basic information

• Product Name: 1-[4-(2-hydroxy-benzylamino)phenyl]-3-phenylurea
• CAS NO: 1173492-73-3
• Molecular Weight: 333.39
• Mol File: 1173492-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(2-hydroxy-benzylamino)phenyl]-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-hydroxy-benzylamino)phenyl]-3-phenylurea(1173492-73-3)
• EPA Substance Registry System: 1-[4-(2-hydroxy-benzylamino)phenyl]-3-phenylurea(1173492-73-3)

Safety Data

• Hazardous Substances Data: 1173492-73-3(Hazardous Substances Data)

Upstream product

• 10141-46-5 1–(4-aminophenyl)-3-phenylurea 
• 90-02-8 salicylaldehyde 

Relevant articles and documents

1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1α inhibitors

A series of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives 2a-r were synthesized as HIF-1α inhibitors. Among the compounds synthesized, compound 2k was found to be a potent inhibitor against HIF-1α accumulation under hypoxic condition and inhibited the hypoxia-induced HIF-1 transcriptional activity in HEK293 cells (IC50 = 7.2 μM). Furthermore, compound 2k suppressed the hypoxia-induced secretion of VEGF in HeLa cells (IC50 = 15 μM).