1173883-99-2Relevant articles and documents
Pyridinium tribromide catalyzed condensation of indoles and aldehydes to form bisindolylalkanes
Yang, Qin,Yin, Zheng Lan,Ouyang, Ban Lai,Peng, Yi Yuan
, p. 515 - 518 (2011)
An efficient synthetic method for bis(indol-3-yl)alkane derivatives has been developed. In the presence of 5 mol% of pyridinium tribromide (PTB), the condensation of indoles and aldehydes proceeded smoothly under mild conditions, giving rise to the corresponding bis(indol-3-yl)alkanes in good to excellent yields.
Nitro-substituted 3,3′-bis(indolyl)methane-modified silica gel as a sorbent for solid-phase extraction of flavonoids
Wang, Na,Liang, Xiaojing,Li, Qian,Liao, Yuan,Shao, Shijun
, p. 15500 - 15506 (2015)
A novel solid-phase extraction (SPE) sorbent was synthesized by chemical immobilization of nitro-substituted 3,3′-bis(indolyl)methane onto pure silica. The nitro-substituted 3,3′-bis(indolyl)methane-modified silica was evaluated by elemental analysis (EA) and Fourier transform infrared spectroscopy (FT-IR). Coupled to high performance liquid chromatography (HPLC), the extraction performance of the sorbent was evaluated by using five flavonoids as model analytes. The results showed that the new sorbent could offer multiple intermolecular interactions, such as π-π, hydrophobic, and hydrogen bonding interactions. Several factors including the extraction material, sample solution pH, sample loading rate, eluent type, volume of eluent, elution rate, and volume of sample loading were optimized. Under the optimal conditions, the proposed method was applied for the analysis of five flavonoids in grape juice. Satisfactory linear ranges for flavonoids were obtained in the range of 10-200 ng mL-1 for myricetin, 5-200 ng mL-1 for quercetin and apigenin, and 1-200 ng mL-1 for luteolin and kaempferol, with correlation coefficients (R) ranging from 0.9908 to 0.9996. Limits of detection (LODs) were in the range of 0.5-10 ng mL-1. The recovery values of spiked grape juice ranged from 91.5% to 120.7% with relative standard deviations (RSDs) less than 9.12% (n = 5). As a novel solid-phase extraction sorbent, the nitro-substituted 3,3′-modified silica exhibited a higher extraction efficiency towards the tested compounds than diol-modified silica.
Bis-indolylation of aldehydes and ketones using silica-supported FeCl3: Molecular docking studies of bisindoles by targeting SARS-CoV-2 main protease binding sites
Deb, Barnali,Debnath, Sudhan,Chakraborty, Ankita,Majumdar, Swapan
, p. 30827 - 30839 (2021/11/19)
We report herein an operationally simple, efficient and versatile procedure for the synthesis of bis-indolylmethanes via the reaction of indoles with aldehydes or ketones in the presence of silica-supported ferric chloride under grindstone conditions. The prepared supported catalyst was characterized by SEM and EDX spectroscopy. The present protocol has several advantages such as shorter reaction time, high yield, avoidance of using harmful organic solvents during the reaction and tolerance of a wide range of functional groups. Molecular docking studies targeted toward the binding site of SARS-CoV-2 main protease (3CLpro or Mpro) enzymes were investigated with the synthesized bis-indoles. Our study revealed that some of the synthesized compounds have potentiality to inhibit the SARS-CoV-2 Mpro enzyme by interacting with key amino acid residues of the active sites via hydrophobic as well as hydrogen bonding interactions.
Phosphine-Free Manganese(II)-Catalyst Enables Acceptorless Dehydrogenative Coupling of Alcohols with Indoles
Yadav, Vinita,Balaraman, Ekambaram,Mhaske, Santosh B.
supporting information, p. 4430 - 4439 (2021/08/03)
Herein, an air-stable, molecularly defined NNN?Mn(II) pincer complex catalyzed acceptorless dehydrogenative coupling of alcohols with indoles is reported. A wide variety of symmetrical and unsymmetrical bis(indolyl)methane derivatives as well as some structurally important products such as Vibrindole A, Turbomycin B alkaloid, Antileukemic, and Anticancer agents were synthesized. Mechanistic studies illustrate the importance of the NH moiety in the complex and the crucial role of metal-ligand cooperation during catalysis. (Figure presented.).
Bimetallic Metal Organic Frameworks as Magnetically Separable Heterogeneous Catalysts and Photocatalytic Dye Degradation
Tiwari, Ashish,Sagara, Prateep Singh,Varma, Vicky,Randhawa, Jaspreet Kaur
, p. 136 - 141 (2019/02/07)
A new bimetallic MOF (BMOF) has been synthesized using iron and zinc as inorganic metal nodes and 1,4-benzenedicarboxylic acid (BDC) as the organic linker molecule. BMOF was confirmed by single-crystal X-ray diffraction (SCXRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy high-angle annular dark-field imaging (TEM-HAADF), field emission scanning electron microscopy energy-dispersive X-ray analysis (FESEM-EDX), vibrating sample magnetometry (VSM) and inductively coupled plasma mass spectrometry (ICP-MS) analysis. The synthesized BMOF shows excellent optical and magnetic properties. BMOF acts as a heterogeneous catalyst and shows high catalytic activity towards bis(indolyl)methane synthesis and photocatalytic degradation of methylene blue (MB) under visible-light illumination.
