117467-72-8

Basic information

• Product Name: (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)propanoic acid
• Synonyms: (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)propanoic acid
• CAS NO: 117467-72-8
• Molecular Weight: 305.354
• Mol File: 117467-72-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)propanoic acid(117467-72-8)
• EPA Substance Registry System: (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)propanoic acid(117467-72-8)

Safety Data

• Hazardous Substances Data: 117467-72-8(Hazardous Substances Data)

Upstream product

• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 
• 89525-07-5 (+/-)-2-<(benzyloxycarbonyl)amino>-2-(dimethoxyphosphinyl)acetic acid 
• 161282-35-5 tert-butyl (Z)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)prop-2-enoate 
• 118553-53-0 rac-tert-butyl 2-<(benzyloxy)carbonylamino>-2-(dimethoxyphosphoryl)-acetate 
• 98-03-3 thiophene-2-carbaldehyde 
• 634920-02-8 4-thiophen-2-ylmethyl-oxazolidine-2,5-dione 
• 2021-58-1 rac-3-(2-thienyl)alanine 
• 394210-39-0 2,5-dioxo-4-thiophen-2-ylmethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 161282-52-6 tert-butyl (R)-2-<(benzyloxy)carbonylamino>-3-(thiophen-2-yl)propanoate 

Downstream Products

• 1054646-21-7 ((1R,2S,3S,4R)-4-Benzyloxycarbonylamino-2,3-dihydroxy-5-thiophen-2-yl-1-thiophen-2-ylmethyl-pentyl)-carbamic acid benzyl ester 

Relevant articles and documents

NOVEL OPTICALLY ACTIVE COMPOUNDS, METHOD FOR KINETIC OPTICAL RESOLUTION OF CARBOXYLIC ACID DERIVATIVES AND CATALYSTS THEREFOR

The present invention provides a method of kinetic optical resolution of carboxylic acid derivatives using specific optically active catalysts. A racemic or diastereomeric mixture of carboxylic acid derivatives of the formula (A) is reacted with a nucleophile in the presence of an optically active catalyst to form an optically active nucleophile derivative of the formula (B). The catalyst is an optically active compound represented by the formula (C) or (D) [wherein R1 is a substituted or unsubstituted, saturated or unsaturated, straight-chain, branched or alicyclic aliphatic hydrocarbon group which can have a heteroatom, R2 is ethyl or vinyl, and R5 is hydrogen or methoxy respectively].

Synthesis of enantiomerically pure D- and L-(heteroaryl)alanines by asymmetric hydrogenation of (Z)-α-amino-α,β-didehydro esters

Homogeneous asymmetric hydrogenation of a wide range of methyl and tert-butyl (Z)-2-(acylamino)-3-(heteroaryl)acrylates (see 1a-f and 2a-d, f, g, resp.) catalyzed by diphosphinerhodium catalysts was studied for the synthesis of enantiomerically pure 3-fur