117690-52-5

Basic information

• Product Name: Ethanone, 1-[2-hydroxy-4-(4-hydroxybutoxy)-5-(2-propenyl)phenyl]-
• CAS NO: 117690-52-5
• Molecular Formula: C15H20O4
• Molecular Weight: 264.321
• Mol File: 117690-52-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-hydroxy-4-(4-hydroxybutoxy)-5-(2-propenyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-hydroxy-4-(4-hydroxybutoxy)-5-(2-propenyl)phenyl]-(117690-52-5)
• EPA Substance Registry System: Ethanone, 1-[2-hydroxy-4-(4-hydroxybutoxy)-5-(2-propenyl)phenyl]-(117690-52-5)

Safety Data

• Hazardous Substances Data: 117690-52-5(Hazardous Substances Data)

Upstream product

• 33036-62-3 4-Bromo-1-butanol 
• 38987-01-8 5-allyl-2,4-dihydroxyacetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 40815-74-5 4-allyloxy-2-hydroxyacetophenone 
• 117705-59-6 5-allyl-4-hydroxy-2-methoxyacetophenone 
• 117705-60-9 1-(4-allyloxy-2-methoxy-phenyl)-ethanone 

Relevant articles and documents

Leukotriene B4 Receptor Antagonists: The LY255283 Series of Hydroxyacetophenones

A series of hydroxyacetophenones was prepared for evaluation as leukotriene B4 (LTB4) receptor antagonists, culminating in 1-oxy>phenyl>ethanone (compound 35, LY255283).Using an assay for inhibition of specific LTB4 binding to human PMN, we found that substitution of a nonpolar substituent in the 5-position was required for activity.Best activity was realized with hydrogen in the 3-position, hydroxyl in the 2-position, short chain alkyl ketone in the 1-position, and a six- or eight-carbon chain linking the oxygen in the 4-position with an unsaturated terminal function.Compound 35, having an IC50 of 87 nM in the binding assay, was chosen for further preclinical evaluation.