117877-52-8

Basic information

• Product Name: o-nitrobenzyl pyridinium chloride
• Synonyms: o-nitrobenzyl pyridinium chloride
• CAS NO: 117877-52-8
• Molecular Weight: 250.685
• Mol File: 117877-52-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: o-nitrobenzyl pyridinium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: o-nitrobenzyl pyridinium chloride(117877-52-8)
• EPA Substance Registry System: o-nitrobenzyl pyridinium chloride(117877-52-8)

Safety Data

• Hazardous Substances Data: 117877-52-8(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 612-23-7 2-nitrobenzyl chloride 

Downstream Products

• 13664-79-4 2-nitro-benzaldehyde-[N-(4-dimethylamino-phenyl)-oxime ] 

Relevant articles and documents

Nitrobenzyl esters as potential conjugated alkylating and differentiation promoting agents: Antitumor effect in vivo

A series of ortho and para-nitrobenzyl esters of short chain fatty acids (C2 to C5) and of the lipophilic aminoacid, L-valine, and some other o-nitrobenzylated products were prepared. Bioreductive or hydrolytic cleavages of these compounds could release both differentiation promoting agents such as butyric acid and electrophilic moieties able to alkylate DNA. The antitumor effects of these compounds, either alone and/or associated with an immunostimulating agent (corynebacterium parvum, CP) or interferon (IFN) treatment, was studied using the 180 TG Crocker Sarcoma grafted onto Swiss mice. Based on the mean survival time and the final survival rate, the most active compounds used alone were the o-nitrobenzyl acetate and the 0-nitrobenzyl butyrate. Previous stimulation of the immune competent cells by CP before antitumor treatment increased the efficiency of most of the nitrobenzylated derivatives studied. The association with IFN did not significantly improve the antitumor effect.