1179-87-9 Usage
Description
16-alpha,17-dihydroxy-alpha-methylbenzylidenedioxyprogesterone, also known as Algestone, is a synthetic steroid hormone derived from the formal condensation of the hydroxy groups of algestone with acetophenone. It is a 20-oxo steroid with a cyclic ketal structure, exhibiting hormonal properties similar to those of progesterone.
Uses
Used in Pharmaceutical Industry:
16-alpha,17-dihydroxy-alpha-methylbenzylidenedioxyprogesterone is used as a progestin hormone for various medical applications, including contraception, hormone replacement therapy, and treatment of menstrual disorders. It helps regulate the menstrual cycle, prevents ovulation, and provides relief from symptoms associated with hormonal imbalances.
Used in Contraceptive Applications:
In the contraceptive industry, 16-alpha,17-dihydroxy-alpha-methylbenzylidenedioxyprogesterone is used as a progestin component in combined oral contraceptives. It works synergistically with estrogen to prevent ovulation, thicken cervical mucus, and alter the endometrial lining, thereby reducing the chances of pregnancy.
Used in Hormone Replacement Therapy:
In the field of hormone replacement therapy, 16-alpha,17-dihydroxy-alpha-methylbenzylidenedioxyprogesterone is used as a progestin to counteract the effects of estrogen and help alleviate symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. It also helps maintain bone density and reduce the risk of osteoporosis.
Used in Treatment of Menstrual Disorders:
16-alpha,17-dihydroxy-alpha-methylbenzylidenedioxyprogesterone is used as a therapeutic agent for the treatment of various menstrual disorders, such as dysmenorrhea, amenorrhea, and irregular menstrual cycles. It helps regulate hormonal balance and promotes a more regular menstrual cycle, providing relief from associated symptoms.
Check Digit Verification of cas no
The CAS Registry Mumber 1179-87-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,7 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1179-87:
(6*1)+(5*1)+(4*7)+(3*9)+(2*8)+(1*7)=89
89 % 10 = 9
So 1179-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C29H36O4/c1-18(30)29-25(32-26(33-29)15-19-7-5-4-6-8-19)17-24-22-10-9-20-16-21(31)11-13-27(20,2)23(22)12-14-28(24,29)3/h4-8,16,22-26H,9-15,17H2,1-3H3
1179-87-9Relevant articles and documents
Preparation method of algestone acetophenide
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Paragraph 0026; 0033; 0038; 0043; 0048; 0053; 0054; 0055, (2017/07/21)
The invention discloses a preparation method of algestone acetophenide. The preparation method comprises the following steps: (1) performing reaction among androstenedione cyanohydrin ketal, 1 to 1.5 times amount of substance of phosphorus oxychloride and 1 to 10 times amount of substance of an alkaline medium for 1 to 5h at the reaction temperature of -10 to 80 DEG C to obtain a suppressor; (2) performing reaction between the suppressor and 1 to 10 times amount of substance of methyl magnesium chloride for 1 to 5h at the reaction temperature of -10 to 70 DEG C to obtain a Grignard's product; (3) performing reaction between the Grignard's product and 1 to 5 times amount of substance of potassium permanganate for 10 to 60m at the reaction temperature of -10 to 30 DEG C, and then performing reaction between the Grignard's product and 1 to 5 times amount of substance of acid for 1 to 10h at the reaction temperature of -10 to 30 DEG C to obtain a hydroxy compound; (5) performing reaction among the hydroxy compound, 0.025 to 0.1 time amount of substance of a catalyst and 2 to 10 times amount of substance of acetyl benzene for 1 to 10h at the reaction temperature of -10 to30 DEG C to obtain the algestone acetophenide. Not only the quality and yield of a product are improved, but also the production cost is reduced and the process time is shortened.