117998-08-0Relevant articles and documents
α-CYANO-β-STYRENYL ESTERS FOR AMIDE BOND FORMATION
Roose, B.,Anteunis, M. J. O.,Tavernier, D.
, p. 267 - 270 (2007/10/02)
p-X-α-cyano-β-styrenyl esters (X = H, Cl, CF3, NO2) of N-benzyloxycarbonyl valine were prepared.The rate constant for amide formation with methyl valinate was assayed; it increases with increasing electron attracting power of the para substituent.The N-hydroxysuccinimidoyl ester and the p-H-α-cyano-β-styrenyl ester of valine have comparable reactivities.