118156-56-2

Basic information

• Product Name: N-ethoxycarbonyl-4-piperidinemethanol
• Synonyms: N-ethoxycarbonyl-4-piperidinemethanol;4-(hydroxymethyl)-1-Piperidinecarboxylic acid ethyl ester;4-Hydroxymethyl-piperidine-1-carboxylic acid ethyl ester;Ethyl 4-(hydroxymethyl)
• CAS NO: 118156-56-2
• Molecular Formula: C₉H₁₇NO₃
• Molecular Weight: 187.23618
• Mol File: 118156-56-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 290.2±13.0 °C(Predicted)
• Appearance: /
• Density: 1.100±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: N-ethoxycarbonyl-4-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethoxycarbonyl-4-piperidinemethanol(118156-56-2)
• EPA Substance Registry System: N-ethoxycarbonyl-4-piperidinemethanol(118156-56-2)

Safety Data

• Hazardous Substances Data: 118156-56-2(Hazardous Substances Data)

Usage

General Description

N-ethoxycarbonyl-4-piperidinemethanol is a chemical compound with a molecular formula of C11H19NO3. It is a white to off-white crystalline solid that is commonly used in organic synthesis as a reagent for the preparation of various pharmaceutical compounds. N-ethoxycarbonyl-4-piperidinemethanol is also known for its use as a precursor in the synthesis of other important organic chemicals. The ethoxycarbonyl group in the molecule is important for its reactivity and ability to undergo various chemical transformations, making it a versatile building block in organic chemistry. Additionally, the 4-piperidinemethanol moiety confers biological activity to certain derivatives of N-ethoxycarbonyl-4-piperidinemethanol, making it an important intermediate in the development of pharmaceuticals and bioactive compounds.

Upstream product

• 6457-49-4 4-piperidinemethanol 
• 541-41-3 chloroformic acid ethyl ester 
• 90748-01-9 4-piperidinemethanol hydrochloride 
• 118133-15-6 1-ethoxycarbonylpiperidine-4-carboxylic acid 
• 67-66-3 chloroform 
• 121-44-8 triethylamine 

Downstream Products

• 99658-58-9 ethyl 4-formylpiperidine-1-carboxylate 

Relevant articles and documents

Discovery and SAR of N-(1-((substituted piperidin-4-yl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide derivatives: 5-Hydroxytryptamine receptor 4 agonist as a potent prokinetic agent

A series of novel benzamide derivatives, altering the 4-fluorophenylalkyl moiety in cisapride, were synthesized as 5-HT4 receptor agonists, and SAR of these analogs was examined on in vitro and in vivo prokinetic activities. These compounds were synthesized for high 5-HT4 receptor binding affinities and low hERG affinities. Several types of analogs were obtained and screened for 5-HT4 binding, hERG blocking, agonism, and gastric emptying assessment. Among the analogues, compound 23g showed promising results compared with the other analogs with respect to gastric emptying rates in rats. Therefore, we suggest that it may be a clinical candidate for the development of a potent prokinetic agent to treat GI disorders.

MODULATORS OF MUSCARINIC RECEPTORS

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Modulators of muscarinic receptors

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.