118307-04-3

Basic information

• Product Name: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one
• Synonyms: 5-CHLOROACETYL-6-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE;5-CHLOROACETYL-6-CHLOROOXINDOLE;6-CHLORO-5-(CHLOROACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE;5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indol-2-one;5-CHLOROACETYL-6-CHLOROL-1,3-DIHYDRO-2H-INDOLE-2-ONE;5-cloroacetyl-6-chlorooxindole;5-Chloroacetyl-6-chloro-1,3-dihydroindol-2H-indone-2-one;5-Chloroacetyl-6-chlorol-1,3-d
• CAS NO: 118307-04-3
• Molecular Formula: C₁₀H₇Cl₂NO₂
• Molecular Weight: 244.07
• EINECS: 1533716-785-6
• Product Categories: blocks;IndolesOxindoles;Indoles and derivatives;Indoline & Oxindole;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 118307-04-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 202-206°C
• Boiling Point: 430.1 °C at 760 mmHg
• Flash Point: 213.9 °C
• Appearance: Light brown solid
• Density: 1.471 g/cm³
• Vapor Pressure: 6.54E-08mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 12.55±0.20(Predicted)
• CAS DataBase Reference: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one(118307-04-3)
• EPA Substance Registry System: 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one(118307-04-3)

Safety Data

• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39-24/25
• RIDADR: 3261
• Hazardous Substances Data: 118307-04-3(Hazardous Substances Data)

Usage

Description

5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one, with the CAS number 118307-04-3, is a light brown solid compound that is valuable in the field of organic synthesis. It is characterized by its unique chemical structure, which contributes to its potential applications in various industries.

Uses

Used in Organic Synthesis:
5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one is used as a synthetic building block for the creation of more complex organic molecules. Its chemical properties make it a versatile compound that can be utilized in the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one is used as an intermediate in the synthesis of various drugs. Its unique structure allows for the development of novel therapeutic agents with potential applications in treating a wide range of diseases and medical conditions.
Used in Agrochemical Industry:
5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one is also used in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its incorporation into these products can lead to improved efficacy and selectivity, ultimately contributing to more sustainable agricultural practices.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one is used as a starting material for the production of various dyes and pigments. Its light brown solid form can be transformed into a range of colors, making it a valuable component in the creation of new and improved dyes and pigments for various applications.
Used in Research and Development:
5-Chloroacetyl-6-chloro-1,3-dihydro-2H-indole-2-one is also utilized in research and development settings, where it serves as a key compound for exploring new chemical reactions and understanding the underlying mechanisms of organic synthesis. Its use in this context can lead to the discovery of new synthetic pathways and the development of innovative applications across various industries.

InChI:InChI=1/C10H7Cl2NO2/c11-4-9(14)6-1-5-2-10(15)13-8(5)3-7(6)12/h1,3H,2,4H2,(H,13,15)

Upstream product

• 56341-37-8 6-chloro-2-oxindole 
• 79-04-9 chloroacetyl chloride 
• 89-61-2 2,5-dichloronitrobenzene 
• 147124-32-1 dimethyl (4-chloro-2-nitrophenyl)malonate 

Downstream Products

• 118289-55-7 6-chloro-5-(2-chloroethyl)-2-oxindole 
• 122883-93-6 ziprazidone 
• 884305-08-2 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-hydroxyethyl)-6-chloro-1,3-dihydro-2H-indole-2-one 
• 884305-07-1 5-(2-(4-(1,2-benzisothiazole-3-yl)-1-piperazinyl)-1-oxoethyl)-6-chloro-1,3-dihydro-2H-indole-2-one 
• 884305-06-0 6-chloro-5-(2-chloro-1-hydroxyethyl) indolin-2-one 
• 1156390-49-6 6-chloro-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid 

Relevant articles and documents

Impurity in ziprasidone hydrochloride and preparation method of impurity

The invention provides an impurity in ziprasidone hydrochloride. The impurity has a structure as shown in formula 1. According to the present invention, the impurity with the specific structure is obtained based on incomplete reaction during the ziprasidone hydrochloride preparation process, and the impurity is introduced and transferred to a final product, and the corresponding impurity preparation steps are provided so as to provide the corresponding technical support for the ziprasidone hydrochloride preparation. The synthesis method provided by the invention is simple in process, high in controllability and mild in condition, can be used for quality standard establishment and quality control links such as ziprasidone hydrochloride process research and development, production and the like, and provides technical support for ziprasidone hydrochloride medication safety. The method can be used for quality research such as qualitative and quantitative analysis of impurities in ziprasidone hydrochloride synthesis, so that improvement of the quality of ziprasidone hydrochloride is facilitated, and great guiding significance is provided for reducing the medication risk of ziprasidone hydrochloride.

A SHORT PROCESS FOR THE PREPARATION OF ZIPRASIDONE AND INTERMEDIATES THEREOF

A process for the preparation of oxindole derivative (Ziprasidone hydrochloride) of formula (I) comprising reacting compound of formula (II) with metal or metal compound mineral acid to give compound of formula (III) in a single step which is converted into compound of formula IV which is a key intermediate for the preparation of compound of compound of formula (I).

Ziprasidone process

A process for preparing ziprasidone having low levels of keto ziprasidone and hydroxy ziprasidone impurities.