118380-80-6

Basic information

• Product Name: 5-benzyl-1-(2-acetoxyethoxymethyl)uracil
• CAS NO: 118380-80-6
• Molecular Weight: 318.329
• Mol File: 118380-80-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-benzyl-1-(2-acetoxyethoxymethyl)uracil(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyl-1-(2-acetoxyethoxymethyl)uracil(118380-80-6)
• EPA Substance Registry System: 5-benzyl-1-(2-acetoxyethoxymethyl)uracil(118380-80-6)

Safety Data

• Hazardous Substances Data: 118380-80-6(Hazardous Substances Data)

Upstream product

• 18493-83-9 5-benzyluracil 
• 81777-40-4 2-acetoxyethoxymethyl bromide 
• 2021-28-5 ethyl dihydrocinnamate 
• 25912-36-1 5-benzyl-2-tioxo-2,3-dihydro-pyrimidine-4(1H)-one 
• 96328-46-0 5-benzyl-2,4-bis(trimethylsilyloxy)pyrimidine 
• 59278-00-1 2-acetoxyethyl acetoxymethyl ether 

Downstream Products

• 82857-69-0 5-Benzylacyclouridine 

Relevant articles and documents

Inhibition of uridine phosphorylase. Synthesis and structure-Activity relationships of aryl-substituted 1-((2-hydroxyethoxy)methyl)-5-(3- phenoxybenzyl)uracil

Structure-activity relationship studies on a series of 1-((2- hydroxyethoxy)methyl)-5-(3-(substituted-phenoxy)benzyl)uracils as inhibitors of murine liver uridine phosphorylase have led to compounds with IC50s as low as 1.4 nM. The two most potent compounds, 10j (3-cyanophenoxy) and 11f (3-chlorophenoxy) were tested in vive for effects on steady-state concentrations of circulating uridine in mice and rats. Both compounds were substantially more efficacious than BAU (5-benzylacyclouridine) both in vitro and in vivo.

A NEW METHOD FOR THE SYNTHESIS OF 5-BENZYL-1-(2-HYDROXYETHOXY METHYL)URACIL (BAU), A POTENT URIDINE PHOSPHORYLASE INHIBITOR, AND ITS N3-AND N1,N3-SUBSTITUTED ANALOGS

A new mmethodology for the synthesis of 5-benzyl-1-(2-hydroxyethoxy methyl)uracil (BAU) (1), a potent uridine phosphorylase inhibitor, has been developed.The couping of bis(trimethylsilyl) derivative of 5-brnzyl uracil with 2-acetoxyethoxymethyl bromide,