1185189-58-5

Basic information

• Product Name: 5-(3-cyanopiperidin-1-ylmethyl)-4-(3,5-dimethylphenoxy)-3-iodo-6-methylpyridin-2(1H)-one
• CAS NO: 1185189-58-5
• Molecular Weight: 477.345
• Mol File: 1185189-58-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3-cyanopiperidin-1-ylmethyl)-4-(3,5-dimethylphenoxy)-3-iodo-6-methylpyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-cyanopiperidin-1-ylmethyl)-4-(3,5-dimethylphenoxy)-3-iodo-6-methylpyridin-2(1H)-one(1185189-58-5)
• EPA Substance Registry System: 5-(3-cyanopiperidin-1-ylmethyl)-4-(3,5-dimethylphenoxy)-3-iodo-6-methylpyridin-2(1H)-one(1185189-58-5)

Safety Data

• Hazardous Substances Data: 1185189-58-5(Hazardous Substances Data)

Upstream product

• 1185188-74-2 5-chloromethyl-3-iodo-6-methyl-4-(3,5-dimethylpheoxy)pyridin-2(1H)-one 
• 7492-88-8 piperidine-3-carbonitrile hydrochloride 

Relevant articles and documents

Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-iodopyridin-2(1H)-one type anti-HIV agents

A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin- 2(1H)-ones has been synthesized as new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones (14 and 15). Biological studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, compounds 93 and 99 are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains.