1186089-54-2Relevant articles and documents
A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists
McKinnell, R. Murray,Armstrong, Scott R.,Beattie, David T.,Choi, Seok-Ki,Fatheree, Paul R.,Gendron, Roland A. L.,Goldblum, Adam,Humphrey, Patrick P.,Long, Daniel D.,Marquess, Daniel G.,Shaw,Smith, Jacqueline A. M.,Turner, S. Derek,Vickery, Ross G.
experimental part, p. 5330 - 5343 (2010/04/29)
5-HT4 receptor agonists such as tegaserod have demonstrated efficacy in the treatment of constipation predominant irritable bowel syndrome (IBS-C), a highly prevalent disorder characterized by chronic constipation and impairment of intestinal p