1186194-32-0

Basic information

• Product Name: 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride
• Synonyms: 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride
• CAS NO: 1186194-32-0
• Molecular Weight: 297.71
• Mol File: 1186194-32-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride(1186194-32-0)
• EPA Substance Registry System: 2,6-difluoro-3-(propylsulfonamido)benzoyl chloride(1186194-32-0)

Safety Data

• Hazardous Substances Data: 1186194-32-0(Hazardous Substances Data)

Usage

Chemical structure

A benzoyl chloride derivative containing fluorine, chlorine, nitrogen, oxygen, sulfur, and carbon atoms

Usage

Commonly used as a building block in organic synthesis and pharmaceutical research

Applications

Valuable in the creation of various pharmaceuticals and agrochemicals, as well as in the production of specialty chemicals and materials

Properties and functional groups

Make it a versatile and important compound in the field of chemical and pharmaceutical research.

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 918523-45-2 2,6-difluoro-3-(propane-1-sulfonylamino)-benzoic acid benzyl ester 
• 918523-44-1 3-amino-2,6-difluoro-benzoic acid benzyl ester 
• 1186193-95-2 methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate 
• 1186223-50-6 methyl 2,6-difluoro-3-(propylsulfonamido)benzoate 
• 84832-02-0 methyl 3-amino-2,6-difluorobenzoate 
• 84832-01-9 methyl 2,6-difluoro-3-nitrobenzoate 
• 83141-10-0 2,6-difluoro-3-nitrobenzoic acid 
• 385-00-2 2,6-difluorobenzoic acid 
• 1103234-56-5 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid 

Downstream Products

• 1254565-63-3 propane-1-sulfonic acid {3-[5-(6-chloro-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide 
• 1029872-54-5 vemurafenib 
• 1312940-90-1 N-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-nicotinamide 
• 918504-27-5 N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide 
• 1103232-26-3 N-(6-acetylaminopyridin-3-yl)-2,6-difluoro-3-(propane-1-sulfonylamino)benzamide 

Relevant articles and documents

PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

SUBSTANTIALLY PURE VEMURAFENIB AND ITS SALTS

The present invention relates to a process for the preparation substantially pure propane-1-sulfonicacid-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide or Vemurafenib of Formula (I). The present invention further relates to a process for the preparation substantially pure propane-1-sulfonic acid-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3 -b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide trifluoro methane sulfonic acid salt or Vemurafenib triflate of Formula (VII)

SUBSTANTIALLY PURE VEMURAFENIB AND ITS SALTS

The present Invention relates to a process for the preparation substantially pure propane- 1 -sulfonicacid- { 3 -[5 -(4-chiorophenyI)-1 H-pyrrolo [2,3-b]pyridine-3 -carbonyl]-2,4-difluoro-phenyl} -amide or Vemurafenib of Formula (1), The present invention further relates to a process for the preparation substantially pure propane- 1 -sulfonic acid- { 3 - [5-(4-chlorophenyi)-1H-pyrrolo [2,3-b]pyridine-3 -carbonyl] -2,4-difluoro-phenyl} -amide trifluoro methane sulfonic acid salt or Vemurafenib triflate of Formula (VII).