1186483-60-2

Basic information

• Product Name: 5-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine
• CAS NO: 1186483-60-2
• Molecular Weight: 534.411
• Mol File: 1186483-60-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine(1186483-60-2)
• EPA Substance Registry System: 5-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine(1186483-60-2)

Safety Data

• Hazardous Substances Data: 1186483-60-2(Hazardous Substances Data)

Upstream product

• 153254-09-2 2,4-bis(trifluoromethyl)phenylboronic acid 
• 1186484-99-0 5-(4-bromobenzyl)-2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 
• 18355-73-2 2,3-difluorobenzoyl chloride 
• 2646-91-5 2,3-difluorobenzaldehyde 
• 1105062-49-4 2-(2,3-difluorophenyl)-1H-imidazole-4,5-dicarbonitrile 
• 1105058-57-8 2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine 

Relevant articles and documents

Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism

By reducing the basicity of the core heterocycle in a series of HCV NS5B inhibitors, the hERG liability was reduced. The SAR was then systematically explored in order to increase solubility and enable dose escalation while retaining potency. During this e