1187065-46-8Relevant articles and documents
Biaryl polyamides as a new class of DNA quadruplex-binding ligands
Rahman, Khondaker M.,Reszka, Anthony P.,Gunaratnam, Mekala,Haider, Shozeb M.,Howard, Philip W.,Fox, Keith R.,Neidle, Stephen,Thurston, David E.
, p. 4097 - 4099 (2009)
We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.