1187383-72-7

Basic information

• Product Name: 4-{2-[4-(benzyloxy)phenyl]benzimidazol-6-yl}morpholine
• Synonyms: 4-{2-[4-(benzyloxy)phenyl]benzimidazol-6-yl}morpholine
• CAS NO: 1187383-72-7
• Molecular Weight: 385.466
• Mol File: 1187383-72-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{2-[4-(benzyloxy)phenyl]benzimidazol-6-yl}morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{2-[4-(benzyloxy)phenyl]benzimidazol-6-yl}morpholine(1187383-72-7)
• EPA Substance Registry System: 4-{2-[4-(benzyloxy)phenyl]benzimidazol-6-yl}morpholine(1187383-72-7)

Safety Data

• Hazardous Substances Data: 1187383-72-7(Hazardous Substances Data)

Upstream product

• 54998-00-4 5-morpholino-2-nitroaniline 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 119421-28-2 4-morpholinobenzene-1,2-diamine 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 1187383-66-9 (2S)-N-{4-(5-[2-[(4-(benzyloxy)phenyl)-6-morpholino]benzimidazol-1-yl]pentyl)oxy-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 1187383-55-6 7-methoxy-8-{5-[2-[(4-(benzyloxy)phenyl)-6-morpholino]benzimidazol-1-yl]pentyl}oxy-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one 
• 1187383-65-8 (2S)-N-{4-(5-[2-[(4-(benzyloxy)phenyl)-6-morpholino]benzimidazol-1-yl]pentyl)oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Relevant articles and documents

Synthesis, DNA binding ability and anticancer activity of 2-heteroaryl substituted benzimidazoles linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates

As a continuation of our efforts to develop the benzimidazole-PBD conjugates as potential anticancer agents, a series of heteroaryl substituted benzimidazole linked PBD conjugates has been synthesized and evaluated for their anticancer potential in 60 human cancer cell lines. Most of the compounds exhibited promising anticancer activity and interestingly, compounds 4c and 4d displayed significant activity in most of the cell lines tested. Whereas, compound 4e showed selectivity in renal cancer cells with GI50 values of 10 and 70 nM against RXF 393 and UO-31 cell lines, respectively. Further, these compounds also showed significant DNA-binding affinity by thermal denaturation study using duplex form of calf thymus (CT) DNA.