1188522-91-9

Basic information

• Product Name: 5-BroMo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine
• Synonyms: 5-bromo-2'-deoxy-2'-fluoro-3',5'-diacetateUridine;5-Bromo-2'-deoxy-2'-fluorouridine 3',5'-diacetate;GXBDBWHTVDEDMG-DNRKLUKYSA-N
• CAS NO: 1188522-91-9
• Molecular Formula: C13H14BrFN2O7
• Molecular Weight: 409.1618632
• Mol File: 1188522-91-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-BroMo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BroMo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine(1188522-91-9)
• EPA Substance Registry System: 5-BroMo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine(1188522-91-9)

Safety Data

• Hazardous Substances Data: 1188522-91-9(Hazardous Substances Data)

Usage

Description

5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine is a chemical compound derived from uridine, a nucleoside present in RNA. 5-BroMo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine features bromine, fluorine, and acetyl groups attached to the uridine molecule, which contribute to its unique chemical properties and potential therapeutic applications.

Uses

Used in Pharmaceutical Research:
5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine is utilized as a research compound for its potential applications in the development of antiviral and anticancer drugs. Its distinct chemical structure allows for the exploration of its biological effects and its possible use in medicinal treatments.
Used in Antiviral Drug Development:
In the field of antiviral research, 5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine is employed as a candidate molecule to investigate its ability to inhibit viral replication and infectivity. Its unique chemical composition may offer novel mechanisms for combating viral diseases.
Used in Anticancer Drug Development:
5-Bromo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine is also used in cancer research, where it is studied for its potential to interfere with cancer cell growth and proliferation. Its incorporation into drug development pipelines aims to identify new therapeutic strategies for various types of cancer.
Used in Biochemical Studies:
5-BroMo-2'-deoxy-2'-fluoro-3',5'-di-O-acetyl uridine serves as a valuable tool in biochemical research, providing insights into the mechanisms of nucleic acid synthesis and the role of modified nucleosides in biological processes. Its use in these studies contributes to a broader understanding of molecular biology and the development of targeted therapies.

Upstream product

• 128-08-5 N-Bromosuccinimide 
• 10212-13-2 3’,5’-O-acetyl-2’-deoxy-2’-fluorouridine 
• 56287-17-3 2'-deoxy-2'-fluorouridine 

Downstream Products

• 1188522-96-4 5-bromo-3',5 '-diacetyl-N₄-(2-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine 
• 1188523-02-5 5-bromo-3',5'-diacetyl-N₄-(2,6-dihydroxyphenyl)-2'-fluoro-2'-deoxycytidine 
• 1188523-06-9 3-(2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine 
• 1174063-99-0 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-1,3-diaza-2-oxophenoxazine 
• 1188523-04-7 5-bromo-3',5'-diacetyl-N₄-(2-(2-N-benzylcarbamyl-ethoxy)-6-hydroxyphenyl)-2'-fluoro-2'-deoxycytidine 
• 1178552-81-2 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 
• 1188523-00-3 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 
• 1188523-11-6 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 
• 1188523-08-1 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine 
• 1188523-13-8 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 

Relevant articles and documents

NUCLEIC ACID CHEMICAL MODIFICATIONS

he present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) c