1189124-25-1

Basic information

• Product Name: Boc-Ala-Ala-Thr-Cys-Phe-Ala-Arg-Asn-SH
• CAS NO: 1189124-25-1
• Molecular Weight: 969.153
• Mol File: 1189124-25-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Ala-Ala-Thr-Cys-Phe-Ala-Arg-Asn-SH(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Ala-Ala-Thr-Cys-Phe-Ala-Arg-Asn-SH(1189124-25-1)
• EPA Substance Registry System: Boc-Ala-Ala-Thr-Cys-Phe-Ala-Arg-Asn-SH(1189124-25-1)

Safety Data

• Hazardous Substances Data: 1189124-25-1(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 7536-55-2 N-tert-butyloxycarbonylasparagine 
• 1189124-19-3 N-tert-butoxycarbonyl-O-(9H-fluoren-9-ylmethoxycarbonyl)-L-threonine 
• 862904-81-2 C₄₁H₄₂N₄O₈ 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 84888-35-7 N^α-tert-butyloxycarbonyl-(S)-9-fluorenylmethylcysteine 

Relevant articles and documents

Solid-phase synthesis of peptidyl thioacids employing a 9-fluorenylmethyl thioester-based linker in conjunction with Boc chemistry

(Chemical Equation Presented) A method for the synthesis of peptidyl thioacids is described on the basis of the use of the N-[9-(thiomethyl)-9H- fluoren-2-yl]succinamic acid and cross-linked aminomethyl polystyrene resin. The method employs standard Boc chemistry SPPS techniques in conjunction with 9-fluorenylmethyloxycarbonyl protection of side-chain alcohols and amines and 9-fluorenylmethyl protection of side-chain acids and thiols. Cleavage from the resin is accomplished with piperidine, which also serves to remove the side-chain protection and avoids the HF conditions usually associated with the resin cleavage stage of Boc chemistry SPPS. The so-obtained thioacids are converted to simple thioesters in high yield by standard alkylation according to well-established methods. 2009 American Chemical Society.