119082-97-2

Basic information

• Product Name: 5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID
• Synonyms: BUTTPARK 29\06-23;IFLAB-BB F1956-0007;5-PYRID-2-YL-THIOPHENE-2-CARBOXYLIC ACID;5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID;RARECHEM AL BE 0346;TIMTEC-BB SBB005421;5-(PYRIDIN-2-YL)THIOPHENE-2-CARBOXYLIC ACID;5-Pyrid-2-ylthiophene-2-carboxylice Acid
• CAS NO: 119082-97-2
• Molecular Formula: C₁₀H₇NO₂S
• Molecular Weight: 205.23
• Mol File: 119082-97-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 232-236°C
• Boiling Point: 412°Cat760mmHg
• Flash Point: 203°C
• Appearance: /
• Density: 1.368g/cm³
• Vapor Pressure: 1.58E-07mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID(119082-97-2)
• EPA Substance Registry System: 5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID(119082-97-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37/39
• Hazardous Substances Data: 119082-97-2(Hazardous Substances Data)

Usage

Description

5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID is an organic compound that features a thiophene ring fused with a pyridine ring, and a carboxylic acid group attached to the thiophene. This unique molecular structure endows it with potential biological activities and applications in various fields.

Uses

Used in Pharmaceutical Industry:
5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID is used as a potent histone deacetylase (HDAC) inhibitor for its ability to modulate gene expression and influence cellular processes. As an HDAC inhibitor, it has potential applications in the treatment of various diseases, including cancer, by altering the epigenetic landscape of cells and promoting the re-expression of silenced genes.

InChI:InChI=1/C10H7NO2S/c12-10(13)9-5-4-8(14-9)7-3-1-2-6-11-7/h1-6H,(H,12,13)

Upstream product

• 124-38-9 carbon dioxide 
• 3319-99-1 2'-(2-thienyl)pyridine 
• 123784-07-6 2-(5-bromothiophen-2-yl)pyridine 
• 1003-31-2 thiophene-2-carbonitrile 

Downstream Products

• 119082-98-3 5-(2-pyridinyl)-2-thiophenecarbonyl chloride 
• 1035231-43-6 2-{3-pyridin-3-yl-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl}phenol 
• 863409-60-3 C₂₈H₂₄N₆O₃S 
• 1035232-50-8 3-{3-pyridin-3-yl-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl}phenol 
• 1035232-18-8 2-{5-[(5-phenyl-3-pyridin-3-yl-4,5-dihydro-1H-pyrazol-1-yl)carbonyl]-2-thienyl}pyridine 
• 1035231-54-9 C₂₄H₁₇FN₄O₂S 
• 1035231-83-4 C₂₄H₁₇FN₄O₂S 
• 1035232-28-0 C₂₄H₁₇FN₄O₂S 
• 1035230-80-8 C₂₄H₁₇FN₄O₂S 
• 1265322-53-9 (3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid 

Relevant articles and documents

Coupling of Organotin Reagents with Aryl, Acyl and Heteroaryl Halides Part Two: Synthesis of Thienylpyridine Derivatives

Coupling of organotin reagent Bu3SnAr (Ar = 2- or 3-pyridyl, or 2- or 3-thienyl) with appropriately halogenated heterocyclic in the presence of PdCl(CH2Ph)(PPh3)2 leads to the corresponding thienylpyridine derivative.Functionality is tolerated on the thiophene centre, but not in the case of the corresponding pyridine analogue.The compounds Bu3SnAr were prepared by a variety of methods, giving good yield of the tri-n-butylstannylated heterocycle.Other derivatives are prepared by direct reaction with the thienylpyridine nucleus.Examples of homo-coupling of the both organotin compounds and the aryl halide are also reported.