1192140-15-0

Basic information

• Product Name: 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol
• Synonyms: 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol;5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3(2H)-one
• CAS NO: 1192140-15-0
• Molecular Formula: C14H12N2O
• Molecular Weight: 224.25788
• Mol File: 1192140-15-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.232±0.06 g/cm3(Predicted)
• PKA: 8.16±0.70(Predicted)
• CAS DataBase Reference: 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol(1192140-15-0)
• EPA Substance Registry System: 5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-ol(1192140-15-0)

Safety Data

• Hazardous Substances Data: 1192140-15-0(Hazardous Substances Data)

Upstream product

• 1192140-19-4 2,5-dimethyl-2-(naphthalen-2-yldiazenyl)furan-3(2H)-one 
• 6290-17-1 ethyl 2-(2,4-dimethyl-1,3-dioxolan-2-yl)acetate 
• 2243-58-5 2-naphthylhydrazine hydrochloride 
• 1356907-03-3 2-(2,4-dimethyl-1,3-dioxolan-2-yl)-N'-(naphthalen-2-yl)acetohydrazide 
• 1356907-02-2 2-(2,4-dimethyl-1,3-dioxolan-2-yl)acetic acid 
• 40880-56-6 N′-(naphthalen-2-yl)acetohydrazide 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 878141-96-9 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine 

Relevant articles and documents

Synthesis and biological evaluation of the 1-arylpyrazole class of σ1 receptor antagonists: Identification of 4-{2-[5-methyl-1- (naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

The synthesis and pharmacological activity of a new series of 1-arylpyrazoles as potent σ1 receptor (σ1R) antagonists are reported. The new compounds were evaluated in vitro in human σ1R and guinea pig σ2 receptor (σ2R) binding assays. The nature of the pyrazole substituents was crucial for activity, and a basic amine was shown to be necessary, in accordance with known receptor pharmacophores. A wide variety of amines and spacer lengths between the amino and pyrazole groups were tolerated, but only the ethylenoxy spacer and small cyclic amines provided compounds with sufficient selectivity for σ1R vs σ2R. The most selective compounds were further profiled, and compound 28, 4-{2-[5-methyl-1- (naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862), which showed high activity in the mouse capsaicin model of neurogenic pain, emerged as the most interesting candidate. In addition, compound 28 exerted dose-dependent antinociceptive effects in several neuropathic pain models. This, together with its good physicochemical, safety, and ADME properties, led compound 28 to be selected as clinical candidate.

PROCESS FOR THE PREPARATION OF 1-ARYL-PYRAZOL-3-ONE INTERMEDIATES USEFUL IN THE SYNTHESIS OF SIGMA RECEPTORS INHIBITORS

The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.