119233-39-5Relevant articles and documents
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Butler,Renfrew,Clapp
, p. 1472 (1938)
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Double-hetero atom six-membered ring of synthetic method
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, (2018/07/30)
The invention provides a double-hetero atom six-membered ring of synthetic method. The synthetic method comprises to alkyl substituted cyclopropane and benzyl alcohol and/or a the oxygen radical animal pen is mellow as the starting material, sequentially carry out the ring-opening reaction, a transesterification reaction, 1st sulfonylation reaction, alcoholysis reaction and the nucleophilic substitution reaction, catalytic hydrogenation reaction and 2nd sulfonylation reaction and forming ring reaction, to obtain the required double-hetero atom six-membered ring, a formula (1) of the structure shown. In order to price the comparatively cheap racemic alkyl substituted cyclopropane as raw materials, to participate in the ring-opening reaction, to obtain a ring opening product. Then under the action of the esterase, make the ring-opening products which is a transesterification reaction, disposable obtain the desired racemic compound. This avoids the traditional method of multi-step separation and purification in the synthesis step, shortens the synthetic route. In the above synthetic route also avoids the need to use some dangerous reagent, process more security, reducing waste generation, and save the process cost.
Synthesis of novel acridino- and phenazino-18-crown-6 ligands and their optically pure dimethyl-substituted analogues for molecular recognition studies
Huszthy, Peter,Samu, Erika,Vermes, Borbala,Mezey-Vandor, Gabriella,Nogradi, Mihaly,Bradshaw, Jerald S.,Izatt, Reed M.
, p. 1491 - 1504 (2007/10/03)
Novel acridino- and phenazino-18-crown-6 ligands 5 and 6 were prepared from acridine-4.5-diol (9) and phenazine-1,9-diol (10) with tetraethylene glycol di-p-tosylate (11) using potassium tert-butoxide as a base in THF. New optically pure dimethyl-substitu
