1193-30-2

Basic information

• Product Name: 6-Azaspiro[3.4]octan-5-one
• Synonyms: 6-Azaspiro[3.4]octan-5-one
• CAS NO: 1193-30-2
• Molecular Formula: C7H11NO
• Molecular Weight: 125.16834
• Mol File: 1193-30-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Azaspiro[3.4]octan-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Azaspiro[3.4]octan-5-one(1193-30-2)
• EPA Substance Registry System: 6-Azaspiro[3.4]octan-5-one(1193-30-2)

Safety Data

• Hazardous Substances Data: 1193-30-2(Hazardous Substances Data)

Usage

General Description

6-Azaspiro[3.4]octan-5-one, also known as azabicyclooctanone, is a chemical compound with a unique spirocyclic structure. It is a bicyclic, saturated, nitrogen-containing compound with a seven-membered ring that includes a nitrogen atom. 6-Azaspiro[3.4]octan-5-one has potential applications in pharmaceutical and medicinal chemistry, particularly as a building block for the synthesis of various biologically active compounds. It is also used as a precursor in the synthesis of other nitrogen-containing heterocycles. Additionally, it is known for its use in the production of certain synthetic flavors and fragrances. Its distinctive chemical structure makes it a valuable intermediate in organic synthesis and makes it useful in a wide range of chemical reactions.

Upstream product

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Relevant articles and documents

N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the application. Each substituent are defined in the specification and claims. The series of compounds of the application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.

Reaktionen mit Aziridinen, XXII. Einstufensynthese von Pyrrolidonen durch Amidoethylierung einfacher Ester mit N-Acylaziridinen

Sodium enolates of simple esters (2) react smoothly with N-acylaziridines (3) in THF forming 3-substituted 2-pyrrolidones 8.If the α-position of the ester carries more than one H-atom amidoethylated pyrrolidones can result.Whilst a simple butyrolactone behaves analogously amidoethylation of coumaranone furnished mono and bis amidoethyl derivatives of coumaranone besides a pyrrolidone. - In tert-butyl alcohol only extremly acidic esters like 1e and 1j could be amidoethylated.