1196712-27-2

Basic information

• Product Name: 3-fluoro-1-[(4-methylphenyl)sulfonyl]piperidine
• Synonyms: 3-fluoro-1-[(4-methylphenyl)sulfonyl]piperidine
• CAS NO: 1196712-27-2
• Molecular Weight: 257.329
• Mol File: 1196712-27-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-fluoro-1-[(4-methylphenyl)sulfonyl]piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-1-[(4-methylphenyl)sulfonyl]piperidine(1196712-27-2)
• EPA Substance Registry System: 3-fluoro-1-[(4-methylphenyl)sulfonyl]piperidine(1196712-27-2)

Safety Data

• Hazardous Substances Data: 1196712-27-2(Hazardous Substances Data)

Upstream product

• 5134-62-3 1-tosylpiperidine-3-carboxylic acid 
• 81097-24-7 N-tosyl-(4-pentenyl)amine 

Relevant articles and documents

Hypervalent Iodine/HF Reagents for the Synthesis of 3-Fluoropyrrolidines

The intramolecular aminofluorination of homoallylamine derivatives using a reagent system of PhI(OAc)2 and Py·HF in CH2Cl2 at room temperature for 5 h gave N-tosyl-3-fluoropyrrolidines in good to high yields. Furthermore, the catalytic aminofluorination was furnished by the reaction using p-iodotoluene as a catalyst in the presence of Py·HF as a fluorine source and mCPBA as a terminal oxidant.

Regioselective (Diacetoxyiodo)benzene-promoted halocyclization of unfunctionalized olefins

A metal-free method for intramolecular halocyclization of unfunctionalized olefins was detailed. (Diacetoxyiodo)benzene (PIDA) was very effective for haloamidation, haloetherification, and halolactonization of unfunctionalized olefins. In the presence of

Metal-free intramolecular aminofluorination of alkenes mediated by PhI(OPiv)2/hydrogen fluoride-pyridine system

A convenient, metal-free intramolecular aminofluorination of alkenes has been developed. Employing readily available PhI(OPiv)2 and hydrogen fluoride-pyridine in the presence of BF3·OEt2, tosyl-protected pent-4-en-1-amines were converted to 3-F-piperidines in one step in good yields as well as high stereoselectivity.