1198108-87-0Relevant articles and documents
Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles
Miller, Duncan C.,Klute, Wolfgang,Brown, Alan D.
, p. 6108 - 6111 (2011/11/06)
Optimisation of the potency of a bicyclic CRF antagonist whilst retaining metabolic stability is described. A core change and incorporation of metabolically stable lipophilic groups resulted in a further potency gain without increasing metabolic liability