120016-97-9

Basic information

• Product Name: 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine
• Synonyms: 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine
• CAS NO: 120016-97-9
• Molecular Weight: 679.65
• Mol File: 120016-97-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine(120016-97-9)
• EPA Substance Registry System: 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine(120016-97-9)

Safety Data

• Hazardous Substances Data: 120016-97-9(Hazardous Substances Data)

Upstream product

• 54-42-2 5-Iodo-2'-deoxyuridine 
• 14719-21-2 trifluoroacetyl-propargyl amine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 115899-40-6 2,2,2-trifluoro-N-(3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-yn-1-yl)acetamide 
• 104375-88-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine 

Downstream Products

• 96102-26-0 5-[3-N-(trifluoroacetyl)aminopropyl]-5'-O-(4,4'-dimethyltrityl)-2'deoxyuridine 
• 120016-98-0 5-(3-trifluoroacetamidopropargyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-3'-[(2-cyano-ethyl)-N,N-diisopropylaminophosphoramidite] 
• 339569-43-6 5-(3-aminopropynyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 
• 179101-49-6 5-(3-amino-1-propynyl)-2'-deoxyuridine 5'-triphosphate 
• 244285-86-7 3'-O-acetyl-5-(3''-trifluoroacetamidopropynyl)-5'-O-dimethoxytrityl-2'-deoxyuridine 

Relevant articles and documents

OLIGONUCLEOTIDE LABELLING: A CONCISE SYNTHESIS OF A MODIFIED THYMIDINE PHOSPHORAMIDITE

The condensation of 5'-dimethoxytrityl-5-iodo-2'-deoxyuridine (1) with N-trifluoroacetylpropargylamine (2) in the presence bis(triphenylphosphine) Pd(II) chloride and copper(I) iodide and subsequent conversion to the 3'-phosphoramidite (4) is an efficient

Functionalization of mono- and oligonucleotides with phosphane ligands by amide bond formation

Seven phosphane-functionalized deoxyuridines have been prepared by amide bond formation between aminodeoxyuridines and phosphanylcarboxylic acids. X-ray crystal structures for two of these new modified nucleosides have been obtained. The same coupling method has been extended to oligonucleotides. The phosphane containing strands have been purified and characterized by MALDI-TOF and, for the first time, 31P NMR spectrometry. Coordination of a phosphane-modified 15-mer to a [PdCl(η3-allyl)] moiety has been confirmed by 31P NMR spectroscopy.

Building-block approach for the straightforward incorporation of a new FRET (fluorescence-resonance-energy transfer) system into synthetic DNA

The synthesis of the two new phosphoramidites 5 and 8 bearing a carbostyril (= quinolin-2(1H)-one) chromophore used as donor entity in our recently developed new FRET (fluorescence-resonance-energy transfer) system is described (Schemes 1 and 2) The high