1203-25-4

Basic information

• Product Name: 6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione
• CAS NO: 1203-25-4
• Molecular Formula: C₆H₆ClN₃O₄
• Molecular Weight: 219.5825
• Mol File: 1203-25-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 243.8°C at 760 mmHg
• Flash Point: 101.2°C
• Density: 1.64g/cm³
• Vapor Pressure: 0.0315mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione(1203-25-4)
• EPA Substance Registry System: 6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione(1203-25-4)

Safety Data

• Hazardous Substances Data: 1203-25-4(Hazardous Substances Data)

Usage

Description

6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione is a heterocyclic chemical compound with the molecular formula C6H5ClN4O4. It features a pyrimidine ring structure with a chlorine atom, two methyl groups, and a nitro group attached to it. 6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione holds potential applications across various fields, including pharmaceuticals, agrochemicals, and material science. Due to its potential toxicity or hazardous nature, it is crucial to handle, store, and use this compound with care, adhering to safe laboratory practices and guidelines.

Uses

Used in Pharmaceutical Industry:
6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione serves as an intermediate or active pharmaceutical ingredient in the development of medications targeting various diseases and conditions. Its unique structure allows for specific interactions with biological targets, making it a valuable compound in drug discovery and medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione is utilized as a component in the formulation of pesticides, herbicides, or other crop protection agents. Its chemical properties enable it to effectively manage pests and enhance crop yields.
Used in Material Science:
6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione contributes to the advancement of new materials in material science. Its incorporation into polymers or other materials can lead to the development of novel properties, such as improved stability, enhanced reactivity, or specific binding capabilities, which can be applied in various industries.

Upstream product

• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 769-42-6 1,3-dimethylbarbituric acid 

Downstream Products

• 90994-73-3 6-(4-Chloro-benzylamino)-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 90994-72-2 6-(4-Methoxy-benzylamino)-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 82000-36-0 6-Benzylsulfanyl-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 90994-75-5 6-(Benzyl-methyl-amino)-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 82000-38-2 4,6-Dimethyl-2-(4-nitrophenyl)thiazolo<5,4-d>pyrimidine-5,7-(4H,6H)dione 1-oxide 
• 90994-74-4 1,3-Dimethyl-5-nitro-6-(1-phenyl-ethylamino)-1H-pyrimidine-2,4-dione 
• 60228-90-2 6-benzylamino-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 90994-71-1 1,3-Dimethyl-6-(4-methyl-benzylamino)-5-nitro-1H-pyrimidine-2,4-dione 
• 1128-14-9 5-amino-6-chloro-1,3-dimethyluracil 
• 638212-21-2 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil 
• 29064-02-6 8-(4-chloro-phenyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 967-42-0 8-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione 
• 57196-70-0 8-(p-Tolyl)theophylline 
• 961-45-5 1,3-dimethyl-8-phenylxanthine 

Relevant articles and documents

Doxofylline impurity and preparation method thereof

The invention provides a doxofylline impurity and a preparation method thereof. The impurity is 9-(2,2-dimethoxyethyl)-1,3-dimethyl-1H-purine-2,6(3H,9H)-diketone. A compound provided by the inventioncan be used as a standard substance for detecting ingredients of a doxofylline finished product, thereby improving the accurate positioning and characterization of the detection and analysis of doxofylline finished product for the impurities, strengthening the control of the impurities, and further improving the quality of the doxofylline finished products.

Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions

A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.

Synthesis and anti-HIV activity of new 6-thioarylpyrimidines and related compounds

A series of new 5-nitro- and 5-amino-6-arylsulfanyl-1-propyl-1H-pyrimidin- 2,4-diones (4-9) were synthesized with the aim to develop new non-nucleoside reverse transcriptase inhibitors (NNRTIs). Similarly, 6-arylsulfanyl-1,3- dimethyl-5-nitro-1H-pyrimidin-2,4-diones (12-15) were prepared from 10. A new 2-amino-2-phenyl-7-phenylsulfanyl-imidazo[1,2-a]pyrimidin-5-one (18) has been synthesized from reaction of 17 with α-bromoacetophenone in the presence of NaH. The newly synthesized compounds were evaluated for their anti HIV-1 and HIV-2 activity in MT-4 cells. Copyright Taylor & Francis Group, LLC.