1203-55-0

Basic information

• Product Name: NAPHTHO[2,1-D]THIAZOL-2-YLAMINE
• Synonyms: IFLAB-BB F1386-0396;NAPHTHO[2,1-D][1,3]THIAZOL-2-AMINE;NAPHTHO[2,1-D]THIAZOL-2-YLAMINE;Naphtho[2,1-d]thiazol-2-amine (9CI);Zinc00366319;naphtho[2,1-d][1,3]thiazol-2-amine(SALTDATA: FREE);naphtho[2,1-d]thiazol-2-amine
• CAS NO: 1203-55-0
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.26
• Product Categories: BENZOTHIAZOLE
• Mol File: 1203-55-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 417.1°Cat760mmHg
• Flash Point: 206.1°C
• Appearance: /
• Density: 1.403g/cm³
• Vapor Pressure: 3.63E-07mmHg at 25°C
• Refractive Index: 1.83
• CAS DataBase Reference: NAPHTHO[2,1-D]THIAZOL-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: NAPHTHO[2,1-D]THIAZOL-2-YLAMINE(1203-55-0)
• EPA Substance Registry System: NAPHTHO[2,1-D]THIAZOL-2-YLAMINE(1203-55-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 1203-55-0(Hazardous Substances Data)

Usage

Description

NAPHTHO[2,1-D]THIAZOL-2-YLAMINE is a heterocyclic organic compound characterized by the presence of a thiazol and naphthalene ring fused together. It features an amine functional group attached to the thiazole ring, which contributes to its chemical reactivity and potential applications in various fields.

Uses

Used in Organic Synthesis:
NAPHTHO[2,1-D]THIAZOL-2-YLAMINE is used as a key intermediate in the synthesis of various heterocyclic compounds, which are valuable building blocks for the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
NAPHTHO[2,1-D]THIAZOL-2-YLAMINE is used as a starting material for the development of novel therapeutic agents, particularly those targeting specific biological pathways or receptors. Its unique structure and reactivity make it a promising candidate for the design of new drugs with improved efficacy and selectivity.
Used in OLED Industry:
NAPHTHO[2,1-D]THIAZOL-2-YLAMINE is used as a precursor in the preparation of heteroaryl compounds, which are essential components in the fabrication of organic light-emitting diodes (OLEDs). These compounds contribute to the efficient emission of light and improved device performance in OLED applications.

InChI:InChI=1/C11H8N2S/c12-11-13-9-6-5-7-3-1-2-4-8(7)10(9)14-11/h1-6H,(H2,12,13)

Upstream product

• 17931-25-8 2-chloronaphtho<2,1-d>thiazole 
• 2476-69-9 2-Amino-1-thiocyanatonaphthalene 
• 333-20-0 potassium thioacyanate 
• 91-59-8 naphthalen-2-ylamine 
• 15192-76-4 copper(II) thiocyanate 
• 3394-04-5 naphthalen-2-yl-thiourea 
• 6395-99-9 naphtho[2,1-d]thiazol-2-yl-(triphenyl-λ⁵-phosphanylidene)-amine 
• 14837-64-0 3-amino-3H-naphtho[2,1-d]thiazol-2-ylideneamine 
• 20191-75-7 1-bromo-2-naphthylamine 
• 17356-08-0 thiourea 
• 521980-39-2 1-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl thiocyanate 
• 1166-32-1 N,N'-di(2-naphthyl)thiourea 
• 1636-33-5 2-naphthyl isothiocyanate 
• 2243-58-5 2-naphthylhydrazine hydrochloride 

Downstream Products

• 26130-38-1 1-naphtho[2,1-d]thiazol-2-yl-3-phenyl-urea 
• 63751-48-4 8-[1-(4-nitro-phenyl)-pyrrol-2-ylmethylene]-imidazo[2,1-b]naphtho[2,1-d]thiazol-9-one 
• 63751-45-1 8-(3-nitro-benzylidene)-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 63751-44-0 8-(4-nitro-benzylidene)-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 54223-11-9 9-phenyl-imidazo[2,1-b]naphtho[2,1-d]thiazole 
• 54223-12-0 9-(4-chloro-phenyl)-imidazo[2,1-b]naphtho[2,1-d]thiazole 
• 54295-03-3 9-(4-bromo-phenyl)-imidazo[2,1-b]naphtho[2,1-d]thiazole 
• 56921-81-4 9-(4-ethoxy-phenyl)-naphtho[2,1-d]imidazo[2,1-b]thiazole 
• 65323-42-4 9-(4-methoxy-phenyl)-naphtho[2,1-d]imidazo[2,1-b]thiazole 
• 63751-40-6 8-benzylidene-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 63751-41-7 8-(4-hydroxy-benzylidene)-imidazo[2,1-b]naphtho[2,1-d]thiazol-9-one 
• 63751-43-9 8-(4-isopropyl-benzylidene)-naphtho[2,1-d]imidazo[2,1-b]thiazol-9-one 
• 63751-42-8 8-(2-methoxy-benzylidene)-imidazo[2,1-b]naphtho[2,1-d]thiazol-9-one 
• 53338-20-8 2-aminonaphthalene-1-thiol 

Relevant articles and documents

Visible-light-initiated malic acid-promoted cascade coupling/cyclization of aromatic amines and KSCN to 2-aminobenzothiazoles without photocatalyst

By using ambient air as the oxidant and malic acid as the promoter, a practical method for the preparation of 2-aminobenzothiazoles through visible-light-initiated cascade reaction of aromatic amines and KSCN in eco-friendly bis(methoxypropy)ether under metal-, hazardous additive-, photocatalyst-free conditions was established.

NAPHTHO[2,1 -D]THIAZOLE DERIVATIVES, COMPOSITIONS THEREOF AND METHODS OF TREATING DISORDERS

The present application relates to the compounds of formula (I) that inhibit CDK9, pharmaceutical compositions thereof and methods of making and using the same.

Metal-free synthesis of 2-aminobenzothiazoles via aerobic oxidative cyclization/dehydrogenation of cyclohexanones and thioureas

A metal-free process for the synthesis of 2-aminobenzothiazoles from cyclohexanones and thioureas has been developed using catalytic iodine and molecular oxygen as the oxidant under mild conditions. Various 2-aminobenzothiazoles, 2-aminonaphtho[2,1-d]thiazoles, and 2-aminonaphtho[1,2-d] thiazoles were prepared via this method in satisfactory yields.