120347-97-9

Basic information

• Product Name: 6-benzyl-5-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-7-one
• Synonyms: 6-benzyl-5-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-7-one
• CAS NO: 120347-97-9
• Molecular Weight: 240.261
• Mol File: 120347-97-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-benzyl-5-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-5-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-7-one(120347-97-9)
• EPA Substance Registry System: 6-benzyl-5-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-7-one(120347-97-9)

Safety Data

• Hazardous Substances Data: 120347-97-9(Hazardous Substances Data)

Upstream product

• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 1046121-24-7 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-7-one 

Relevant articles and documents

Potassium Hydroxide-Catalyzed Chemoselective Reduction of Cyclic Imides with Hydrosilanes: Synthesis of ω-Hydroxylactams and Lactams

Potassium hydroxide-catalyzed hydrosilylation exhibits excellent activity and chemoselectivity for the reduction of cyclic imides under mild reaction conditions. The chemoselectivity of the reduction system may be readily tuned by changing the identity an

Regioselective Formation of Hydroxy Lactams from Pyridine-2,3-dicarboximides and their Cyclodehydration to Pyridopyrrolo-fused Heterocyclic Systems

Grignard reactions of pyridine-2,3-dicarboximides involve attack at the carbonyl group closer to the pyridine nitrogen atom to give 7-hydroxypyrrolopyridin-5(7H)-one derivatives.Reduction of the same imides with sodium borohydride gives mixtures of regiosomeric hydroxy lactams, in which the 7-hydroxypyrrolopyridin-5-ones are the major components.Hydroxy lactams derived by either of these two methods from pyridine-2,3-dicarboximides containing N-benzyl, N-2-phenylethyl, N-2-(indol-3-yl)ethyl, or N-biphenyl-2-yl substituents are cyclised by heating in trifluoroacetic or polyphosphoric acid to give derivatives of new pyridopyrrolo-fused heterocyclic systems.

New fused heterocyclic systems derived from pyridine-2,3-dicarboximides

α-Hydroxylactams (8), formed by regioselective reduction or Grignard addition to pyridine-2,3-dicarboximides (7), undergo acid-catalysed cyclodehydration to give the new pyrido[2′,3′: 3,4]-pyrrolo fused heterocyclic systems (10)-(13).