1203608-46-1

Basic information

• Product Name: (E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one
• Synonyms: (E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one
• CAS NO: 1203608-46-1
• Molecular Weight: 272.117
• Mol File: 1203608-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one(1203608-46-1)
• EPA Substance Registry System: (E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one(1203608-46-1)

Safety Data

• Hazardous Substances Data: 1203608-46-1(Hazardous Substances Data)

Upstream product

• 1006-39-9 1-(2-bromo-4-fluorophenyl)ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1203608-52-9 5-(2-bromo-4-fluorophenyl)-1-(4-methoxyphenyl)pyrazole 
• 1203608-50-7 5-(2-bromo-4-fluorophenyl)-1-phenylpyrazole 
• 1203608-53-0 5-(2-bromo-4-fluorophenyl)-1-(4-tert-butylphenyl)pyrazole 
• 1203608-54-1 5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol 
• 1203608-51-8 5-(2-bromo-4-fluorophenyl)-1-(3-trifluoromethylphenyl)pyrazole 

Relevant articles and documents

Toward safer processes for C-C biaryl bond construction: Catalytic direct C-H arylation and tin-free radical coupling in the synthesis of pyrazolophenanthridines

(Chemical Equation Presented) A series of pyrazolo[1,5-f]phenanthridine derivatives has been efficiently synthesized by a short, straightforward sequence. A tandem amine-exchange/heterocyclization of enaminones was successfully applied to the regioselective preparation of 1,5-diarylpyrazole intermediates with structure resemblance to relevant nonsteroidal anti-inflammatory drugs such as celecoxib or tepoxalin. The final key step, cyclization by intramolecular biaryl bond formation, was accomplished by two alternative methodologies: radical coupling and catalytic direct arylation via C-H activation. The scope and limitations of the two methodologies have been explored and their complementariness has been established. In addition, polymer-supported heterogeneous catalysts have been compared with homogeneous analogues. In the radical process, toxic tin derivatives have been avoided in order to employ environmentally safer protocols.