1204312-39-9

Basic information

• Product Name: 2-acetaMido-4-chloro-5-Methylbenzoic acid
• Synonyms: 2-acetaMido-4-chloro-5-Methylbenzoic acid;2-(acetylamino)-4-chloro-5-methylbenzoic acid
• CAS NO: 1204312-39-9
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.6443
• Mol File: 1204312-39-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 432.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.394±0.06 g/cm3(Predicted)
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: 2-acetaMido-4-chloro-5-Methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetaMido-4-chloro-5-Methylbenzoic acid(1204312-39-9)
• EPA Substance Registry System: 2-acetaMido-4-chloro-5-Methylbenzoic acid(1204312-39-9)

Safety Data

• Hazardous Substances Data: 1204312-39-9(Hazardous Substances Data)

Usage

General Description

2-Acetamido-4-chloro-5-methylbenzoic acid is a chemical compound with the molecular formula C10H10N1O3Cl1. It is a derivative of acetylsalicylic acid, and it is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. 2-acetaMido-4-chloro-5-Methylbenzoic acid has both acetyl and amino groups attached to a benzene ring, as well as a chlorine and a methyl group. It is typically used as a building block in the synthesis of other pharmaceutical compounds and may also have potential therapeutic properties due to its structure. The exact uses and properties of 2-acetamido-4-chloro-5-methylbenzoic acid may vary depending on the specific application.

Upstream product

• 201230-82-2 carbon monoxide 
• 7149-79-3 N-(3-chloro-4-methylphenyl)acetamide 
• 124-38-9 carbon dioxide 
• 116010-06-1 N-(2-bromo-5-chloro-4-methylphenyl)acetamide 
• 95-74-9 3-chloro-p-toluidine 

Downstream Products

• 155184-81-9 2-amino-5-methyl-4-chlorobenzoic acid 

Relevant articles and documents

BENZAMIDE DERIVATIVE

The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

Synthetic applications of Pd(II)-catalyzed C-H carboxylation and mechanistic insights: Expedient routes to anthranilic acids, oxazolinones, and quinazolinones

A Pd(II)-catalyzed reaction protocol for the carboxylation of ortho-C-H bonds in anilides to form N-acyl anthranilic acids has been developed. This reaction procedure provides a novel and efficient strategy for the rapid assembly of biologically and pharmaceutically significant molecules, such as benzoxazinones and quinazolinones, from simple anilides without installing and removing an external directing group. The reaction conditions are also amenable to the carboxylation of N-phenyl pyrrolidinones. A monomeric palladacycle containing p-toluenesulfonate as an anionic ligand has been characterized by X-ray crystallography, and the crucial role of p-toluenesulfonic acid in the activation of C-H bonds in the presence of carbon monoxide is discussed. Identification of two key intermediates, a mixed anhydride and benzoxazinone formed by reductive elimination from organometallic Ar(CO)Pd(II)-OTs species, provides mechanistic evidence for a dual-reaction pathway.