1204978-10-8

Basic information

• Product Name: 3-benzyl-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine
• Synonyms: 3-benzyl-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine
• CAS NO: 1204978-10-8
• Molecular Weight: 296.415
• Mol File: 1204978-10-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-benzyl-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzyl-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine(1204978-10-8)
• EPA Substance Registry System: 3-benzyl-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine(1204978-10-8)

Safety Data

• Hazardous Substances Data: 1204978-10-8(Hazardous Substances Data)

Upstream product

• 62673-31-8 benzyl(bromo)zinc 
• 34584-69-5 3,6-dichloro-4,5-dimethylpyridazine 
• 1204978-32-4 3-chloro-4,5-dimethyl-6-((R)-3-methyl-piperazin-1-yl)-pyridazine 
• 1204978-02-8 3-benzyl-6-chloro-4,5-dimethylpyridazine 
• 75336-86-6 (2R)-methylpiperazine 

Downstream Products

• 1204975-11-0 (R)-4-(6-benzyl-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid methyl ester 
• 1204975-40-5 3-Benzyl-4,5-dimethyl-6-[(R)-3-methyl-4-(4-trifluoro-methanesulfonylphenyl)-piperazin-1-yl]-pyridazine 
• 1204975-42-7 LEQ-506 
• 1204976-08-8 (R)-3-(5-(4-(6-benzyl-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl)pyrazin-2-yl)pentan-3-ol 

Relevant articles and documents

Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened

First disclosure: Continued optimization provided a novel type of Smoothened (Smo) antagonist based on a pyridazine core. The compound, NVP-LEQ506, currently in phaseI clinical trials, combines high intrinsic potency and good pharmacokinetic properties resulting in excellent efficacy in rodent tumor models of medulloblastoma. Activity against a Smo mutant conferring resistance observed in a previous clinical trial with a competitor compound suggests additional therapeutic potential.