120638-55-3 Usage
Description
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate, also known as Bromfenac, is a non-steroidal anti-inflammatory agent (NSAID) with potent analgesic and anti-inflammatory properties. It is structurally similar to ketoprofen and diclofenac and is used to manage ocular pain and treat postoperative inflammation in patients who have undergone cataract extraction. Bromfenac works by reducing prostaglandin production through the inhibition of cyclooxygenase, leading to its analgesic and anti-inflammatory effects.
Uses
Used in Ophthalmology:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is used as an ophthalmic solution for the treatment of postoperative inflammation and reduction of ocular pain in patients after cataract extraction. It is applied topically to the affected eye twice daily, starting 24 hours after surgery and continuing for the first 2 weeks of the postoperative period.
Used in Non-Steroidal Anti-Inflammatory Therapy:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is used as a non-steroidal anti-inflammatory agent for managing pain and inflammation. It is particularly effective in the rapid resolution of ocular pain after cataract surgery, with statistically significant differences demonstrated between the bromfenac and placebo groups in phase III clinical trials.
Used in Comparative Investigations:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is used as a therapeutic agent in the treatment of external or anterior ocular inflammatory diseases, allergic conjunctivitis, scleritis, and postoperative inflammation. Its clinical safety and efficacy have been extensively studied in diverse comparative investigations.
Chemical Properties:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate is a yellow solid with the brand name Xibrom (Ista). It is the sesquihydrate of the sodium salt of bromfenac and is known for its potent analgesic and anti-inflammatory effects, making it a valuable compound in the field of ophthalmology and pain management.
Originator
American Home Products (US)
Check Digit Verification of cas no
The CAS Registry Mumber 120638-55-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,6,3 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120638-55:
(8*1)+(7*2)+(6*0)+(5*6)+(4*3)+(3*8)+(2*5)+(1*5)=103
103 % 10 = 3
So 120638-55-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H12BrNO3.Na.H2O/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;;/h1-7H,8,17H2,(H,18,19);;1H2/q;+1;/p-1
