1210-97-5Relevant articles and documents
BICYCLIC HETEROCYCLIC DERIVATIVE
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Page/Page column 129, (2010/11/04)
The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R1a is halogen, etc.; R1m is H, etc.; G1 is -N(R1b/s
Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells
Gita, Haruhisa,Sobe, Yoshiaki,Akaku, Haruo,Ekine, Rena,Oto, Yuso,Isawa, Satoru,Hayashi, Hideya
, p. 549 - 551 (2007/10/03)
A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity.
Contrasting Behaviors in the Cleavage of Aryl Alkanoates by α- and β-Cyclodextrins in Basic Aqueous Solution
Tee, Oswald S.,Du, Xian-xian
, p. 1837 - 1839 (2007/10/02)
The kinetics of ester cleavage of 4-carboxy-2-nitrophenyl alkanoates (C2, C4, C6, C7, C8) in aqueous base containing α- or β-cyclodextrin (α- or β-CD) indicate that for the three longer esters there are processes involving two CD molecules which are quite distinct: with α-CD a 2:1 binding leads to inhibition; with β-CD a second-order process provides catalysis.