1213648-37-3Relevant articles and documents
(±)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents
Dukat, Ma?gorzata,Taroua, Mohamed,Dahdouh, Abdelaziz,Siripurapu, Umamaheswar,Damaj, M. Imad,Martin, Billy R.,Glennon, Richard A.
, p. 3651 - 3654 (2004)
Several amine-substituted 8-amino-5,6,7,8-tetrahydroisoquinolines were examined as conformationally-constrained analogs of the nicotinic cholinergic (nACh) 3-(aminomethyl)pyridines. Although these ligands failed to bind at nACh receptors, the N-ethyl-N-methyl analog 3d was found to be at least equipotent with nicotine in rodent tests of antinociception. The mechanism of action of 3d is currently unknown.