121373-20-4

Basic information

• Product Name: Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite
• Synonyms: Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite;iPr2N-P-(OTSE)2;Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite;Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite 96%;bis-[2-(trimethylsiyl)ethoxy]-N,N-diisopropylamidophosphine
• CAS NO: 121373-20-4
• Molecular Formula: C₁₆H₄₀NO₂PSi₂
• Molecular Weight: 365.65
• Mol File: 121373-20-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 286.2-296.6°C
• Flash Point: >110℃
• Appearance: /
• Density: 0.8887 g/mL at 25 °C
• Refractive Index: n20/D1.4517
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite(121373-20-4)
• EPA Substance Registry System: Bis(2-(trimethylsilyl)ethyl) diisopropylphosphoramidite(121373-20-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 121373-20-4(Hazardous Substances Data)

Usage

Uses

Phosphitylation agent used in the preparation of oligonucleotides

Upstream product

• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 921-26-6 N,N-diisopropylphosphoramide dichloride 
• 108-18-9 diisopropylamine 

Downstream Products

• 1026872-20-7 Phosphorous acid 1-methyl-3-phenyl-propyl ester bis-(2-trimethylsilanyl-ethyl) ester 
• 158817-09-5 N^α-(9-fluorenylmethyloxycarbonyl)-O-phosphono>tyrosine 
• 1197420-26-0 (R)-2-(4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)-1-cyclopropylethyl bis(2-(trimethylsilyl)ethyl)phosphate 

Relevant articles and documents

N,N-diisopropyl-bis[2-(trimethylsilyl)ethyl]phosphoramidite. An attractive phosphitylating agent compatible with the Fmoc/t-butyl strategy for the synthesis of phosphotyrosine containing peptides

A new phosphitylating agent, compatible with the Fmoc/t-butyl strategy for the production of phosphotyrosine containing peptides was synthesized. Our results demonstrated that high yields and high purities of phosphotyrosine peptides can be obtained using this phosphitylating agent.

HYDROXY SUBSTITUTED THIENO PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present invention provides compounds having the following Formula IA and IB, which are useful as MCHR1 antagonists, and includes prodrugs and pharmaceutically acceptable salts thereof:

Use of Bis N,N-Dialkylphosphoramidites for the Synthesis of Phosphate Monoesters

The bis N,N-dialkylphosphoramidites 7a and b and bis N,N-dialkylphosphoramidites 6a and b have been prepared by reaction of the N,N-dialkylphosphorochloridites 5a and b with the appropriate 2-(trialkylsilyl)ethanol.In the presence of 1H-tetrazole, the phosphoramidites 6a, b and 7a, b phosphorylated MeOH, PhCH2OH, PhCH2CH2OH, Me(PhCH2CH2(CHOH, 2,3,4,5,6-penta-O-benzyl-myo-inositol and ButOH, to give the phosphites 8a-h.Without isolation, these were oxidized to the corresponding phosphate triesters 9a-h with m-chloroperbenzoic acid.Treatment of the triesters 9a-h with tetrabutylammonium fluoride removes only 2-(trialkylsilyl)ethyl group to give the diesters 10a-h, whereas treatment with a solution of hydrofluoric acid in acetonitrile-water gives the phosphate monoesters 11a-e.